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Sample Size Calculation of Clinical Trials in Geriatric Medicine
Aging Clinical and Experimental Research, 2021 A preliminary step when planning a randomized clinical trial (RCT) is the sample size calculation. This is the determination of the optimal number of patients which ensures an adequate power to the study to detect as statistically significant a certain ...
Giovanni Tripepi +2 more
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Simple sample size calculation
Journal of Evaluation in Clinical Practice, 2007© 2007 The Authors. Journal compilation © 2007 Blackwell Publishing Ltd, Journal of Evaluation in Clinical Practice 13 (2007) 952–953 Journal of Evaluation in Clinical Practice ISSN 1356-1294 Blackwell Publishing LtdOxford, UKJEPJournal of Evaluation in Clinical Practice1356 1294© 2006 The Authors; Journal compilation © 2006 Blackwell Publishing ...
David J, Torgerson, Jeremy N V, Miles
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BMJ, 2010
A randomised controlled trial investigated whether a computerised feedback device modified eating behaviour and resulted in weight loss in obese adolescents.1 The primary outcome was change in body mass index (BMI) from recruitment to 12 months. BMI was calculated as weight (kg)/[height (m)]2, adjusted for age and sex.
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A randomised controlled trial investigated whether a computerised feedback device modified eating behaviour and resulted in weight loss in obese adolescents.1 The primary outcome was change in body mass index (BMI) from recruitment to 12 months. BMI was calculated as weight (kg)/[height (m)]2, adjusted for age and sex.
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2017
Expanding on the discussion of sample size as noted in Chap. 14, this chapter covers the importance of sample size estimation in clinical trials involving invasive operative and nonoperative procedures. It focuses on the key elements for sample size determination that includes acquiring a reliable estimate of the treatment effect and variability, the ...
Eileen M. Stock, Kousick Biswas
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Expanding on the discussion of sample size as noted in Chap. 14, this chapter covers the importance of sample size estimation in clinical trials involving invasive operative and nonoperative procedures. It focuses on the key elements for sample size determination that includes acquiring a reliable estimate of the treatment effect and variability, the ...
Eileen M. Stock, Kousick Biswas
openaire +1 more source
2018
In this chapter the basic principles of sample size calculation are discussed. The chapter also reviews the impact of sample size calculation on the study results, the parameters needed, and ways this calculation can be performed by researchers.
Mohammad Azfar Qureshi +2 more
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In this chapter the basic principles of sample size calculation are discussed. The chapter also reviews the impact of sample size calculation on the study results, the parameters needed, and ways this calculation can be performed by researchers.
Mohammad Azfar Qureshi +2 more
openaire +1 more source
Sample Size Calculations for Ophthalmologic Studies
Archives of Ophthalmology, 1992Sample size calculations are shown for some common ophthalmologic study designs in which two treatments are to be compared. Included are the following three designs: 1, only one eye per subject; 2, both eyes, with each eye assigned to a different treatment; and 3, both eyes undergoing a common treatment.
W J, Gauderman, W E, Barlow
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2016
Just like with continuous outcome data (Chap. 12), with binary outcome data an essential part of the study protocol is the assessment of the question, how many subject need to be studied in order to answer the studies’ objectives. This chapter provides equations that can be used for the purpose if your outcome data are binary.
Ton J. Cleophas, Aeilko H. Zwinderman
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Just like with continuous outcome data (Chap. 12), with binary outcome data an essential part of the study protocol is the assessment of the question, how many subject need to be studied in order to answer the studies’ objectives. This chapter provides equations that can be used for the purpose if your outcome data are binary.
Ton J. Cleophas, Aeilko H. Zwinderman
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Sample size calculations for evaluating mediation
Statistics in Medicine, 2008Abstract This paper presents sample size calculations for testing the mediation of the effect of a primary predictor by an intermediate variable. This problem is related to validating surrogate markers and to testing the effect of a primary predictor in the presence of confounders.
E, Vittinghoff, S, Sen, C E, McCulloch
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Proposals for Sample Size Calculation Programs
Methods of Information in Medicine, 2007Summary Objectives : Numerous sample size calculation programs are available nowadays. They include both commercial products as well as public domain and open source applications. We propose modifications for these programs in order to even better support statistical consultation during the planning stage of a two-armed
H, Heinzl +3 more
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