Results 131 to 140 of about 3,758,239 (336)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

THE IMPACT OF LOCAL LABOR MARKET CONDITIONS ON THE OFF-FARM EARNINGS OF FARM OPERATORS [PDF]

open access: yes
Local labor market characteristics are theoretically relevant to the determination of off-farm earnings of farm operators, but the empirical analysis of these effects has been hindered by a lack of appropriate data.
Gunter, Lewell F., McNamara, Kevin T.
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

The Determination of Sample Size

open access: yesAmerican Journal of Public Health and the Nations Health, 1951
IN the early stages of planning a sample survey one is ordinarily concerned with two different sets of questions, both relating to the survey's feasibility. First of all one is concerned with the possibility of obtaining the required information from the type of respondent considered.
openaire   +3 more sources

On Sample Size Determination

open access: yesMATHEMATICAL JOURNAL OF INTERDISCIPLINARY SCIENCES, 2014
One of the questions most frequently asked of a statistician is: how big should the sample be? Managers are anxious to obtain an answer to this fundamental question during the planning phase of the survey since it impacts directly on operational considerations such as the number of interviewers required.
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Sampling Methods and Sample Size Determination in Clinical Research: An Educational Review

open access: yesJournal of General and Family Medicine
Clinical research validity depends critically on sound sampling methodology and adequate sample size determination, yet many published studies demonstrate deficiencies in these fundamental aspects.
Azzam Zrineh   +2 more
doaj   +1 more source

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