Results 81 to 90 of about 3,758,239 (336)

Optimal sample size determination in adaptive seamless phase II/III design [PDF]

, 2016
The adaptive seamless phase II/III design combines the conventional separate phases II and III trials into a single trial, and it allows for adaptations (e.g. sample size reassessment and early stopping for futility or success) after the interim analysis.
Xu, Zhongying
core  

OSSOS VI. Striking Biases in the detection of large semimajor axis Trans-Neptunian Objects [PDF]

, 2017
The accumulating, but small, set of large semi-major axis trans-Neptunian objects (TNOs) shows an apparent clustering in the orientations of their orbits.
Alexandersen, Mike, Bannister, Michele, Chen, Ying-Tung, Gladman, Brett, Gwyn, Stephen, Jakubik, Marian, Kaib, Nathan, Kavelaars, JJ, Lawler, Samantha, Petit, Jean-Marc, Shankman, Cory, Volk, Kathryn   +11 more
core   +2 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Sample Size Determination in Randomised Controlled Clinical Trials: A Narrative Review [PDF]

Journal of Clinical and Diagnostic Research
This article summarises efforts towards understanding the calculation of sample size determination in Randomised controlled Clinical Trials (RCTs). Readers would gain insight into the procedures behind sample size calculation in RCTs and its significance.
Rakesh Diliprao Kothavale, Yogesh Pradip Patil, Savita Shamkant Mahajan, Yogita Arun Ghuge   +3 more
doaj   +1 more source

Nested Maximum Entropy Designs for Computer Experiments

Mathematics, 2023
Presently, computer experiments with multiple levels of accuracy are widely applied in science and engineering. This paper introduces a class of nested maximum entropy designs for such computer experiments.
Weiyan Mu, Chengxin Liu, Shifeng Xiong
doaj   +1 more source

Improved Outcomes for Older Children, Adolescents, and Young Adults With Neuroblastoma in the Post‐Immunotherapy Era: An Updated Report From the International Neuroblastoma Risk Group

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background We describe clinical and biologic characteristics of neuroblastoma in older children, adolescents, and young adults (OCAYA); describe survival outcomes in the post‐immunotherapy era; and identify if there is an age cut‐off that best discriminates outcomes.
Rebecca J. Deyell, Kavitha Srivatsa, Paola Angelini, Pei‐Chi Kao, Brady Payne, Arlene Naranjo, Sveva Castelli, Miho Kato, Miki Ohira, Ulriche Pöetschger, Yaël Mossé, Lucas Moreno, Meredith S. Irwin, Ramya Ramanujachar, Wendy B. London   +14 more
wiley   +1 more source

Laser Spectroscopic Measurement of Helium Isotope Ratios

, 2003
A sensitive laser spectroscopic method has been applied to the quantitative determination of the isotope ratio of helium at the level of 3He/4He = 10^-7 - 10^-5.
Bjoklund, Clarke, Craig, Hall, Kudryavtsev, Kurz, L.-B. Wang, Lupton, Ma, Mamyrin, Mamyrin, Marcantonio, Matsuda, Modugno, Morrison, Pepin, Petrov, Sano, Schlosser, Sturchio, Supplee, Torgerson, Wang, Wittenberg, Zhao   +24 more
core   +1 more source

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Equivalence Test and Sample Size Determination Based on Odds Ratio in an AB/BA Crossover Study with Binary Outcomes

Axioms
Crossover trials are specifically designed to evaluate treatment effects within individual participants through within-subject comparisons. In a standard AB/BA crossover trial, participants are randomly allocated to one of two treatment sequences: either
Shi-Fang Qiu, Xue-Qin Yu, Wai-Yin Poon
doaj   +1 more source

Determination of minimum training sample size for microarray-based cancer outcome prediction-an empirical assessment. [PDF]

PLoS ONE, 2013
The promise of microarray technology in providing prediction classifiers for cancer outcome estimation has been confirmed by a number of demonstrable successes.
Li Shao, Xiaohui Fan, Ningtao Cheng, Leihong Wu, Yiyu Cheng   +4 more
doaj   +1 more source