From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Two-stage versus sequential sample-size determination in regression analysis of simulation experiments [PDF]
Regression Analysis;Experimental Design;Simulation Models ...
Groenendaal, W.J.H. van +1 more
core +1 more source
Faktor-Faktor Yang Mempengaruhi Penetapan Audit Fees (Studi Empiris Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2014-2016) [PDF]
, 2018 This research was conducted to examine the factors that may affect the determination of the external audit fees on companies listed in Indonesia Stock Exchange (IDX).
, Dra. Nursiam, M.H., Ak., CA +1 more
core
Point-biserial correlation: Interval estimation, hypothesis testing, meta-analysis, and sample size determination. [PDF]
, 2020 The point-biserial correlation is a commonly used measure of effect size in two-group designs. New estimators of point-biserial correlation are derived from different forms of a standardized mean difference.
Bonett, Douglas G
core
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
The Understanding on How to Determine Sample Size in Psychological Science: Data and Simulation
Jurnal Psikologi, 2019 The lack of knowledge on how to determine sample sizes in experiments is arguably one of the main reasons underlying the replication crisis in psychological science. A survey distributed among Indonesian students and researchers concerning 1) familiarity
Wisnu Wiradhany +3 more
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
An elaboration on sample size determination for correlations based on effect sizes and confidence interval width: a guide for researchers [PDF]
Restorative Dentistry & EndodonticsObjectivesThis paper aims to serve as a useful guide for sample size determination for various correlation analyses that are based on effect sizes and confidence interval width.Materials and MethodsSample size determinations are calculated for Pearson’s ...
Mohamad Adam Bujang
doaj +1 more source
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source