Results 191 to 200 of about 10,606,980 (298)

Office of the State Long Term Care Ombudsman ... Annual Report

, 2013
Kansas. Long Term Care Ombudsman
core  

Multifunctional PVA composite pads enabled by carvacrol-loaded ZIF-8@PAN microspheres: sustained carvacrol release and long-term blueberry preservation. [PDF]

Food Chem X
Liu R, Cheng Y, Peng Y, Fan X, Xie S, Liu B, Qi R, Yang L, Zhang C, Xia H, Wang J.   +10 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Prospective evaluation of real-world safety, symptoms improvement and adherence to mavacamten among Iranian patients with hypertrophic obstructive cardiomyopathy (PERSIA-HOCM): protocol of a multicentre observational study. [PDF]

BMJ Open
Ghaseminejad-Raeini A, Karimi MA, Shirinezhad A, Aslani M, Soheili A, Ghaderi A, Haghjoo M, Bakhshandeh H, Naderi N.   +8 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Long-Term Trajectories of Multidimensional Outcomes in Psychosis Following Early Intervention During the Critical Period: The PEPP-Montreal 10+ Study Protocol. [PDF]

Early Interv Psychiatry
Percie du Sert O, Ghanem J, McGrory V, Anselmo K, Anderson KK, Iyer S, Joober R, Shah J, Malla A, Lepage M.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Office of the State Long Term Care Ombudsman ... Annual Report

, 2011
Kansas. Long Term Care Ombudsman
core