Results 241 to 250 of about 13,047,740 (287)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Radiological characteristics of coal-to-ash transformation: a paired coal-ash assessment of natural radionuclides. [PDF]

Environ Geochem Health
Łukaszek-Chmielewska A, Rachwał M, Rakowska J, Piotrowska B, Isajenko K, Szyłak-Szydłowski M.   +5 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Effects of Metal Doping on the Structure and Water-Gas Shift Reaction Performance of Copper-Manganese Catalysts. [PDF]

Molecules
Wu F, He R, Hu Q, Saishengtai G.
europepmc   +1 more source

Adjusting for Medication Use in GWAS and Its Impact on Mendelian Randomisation Analyses: An Example of Systolic Blood Pressure in UK Biobank. [PDF]

Genet Epidemiol
Yap AJY, Hanson AL, Griffith GJ, Sanderson E.   +3 more
europepmc   +1 more source

Age- and Sex-Specific Optimal Cutoffs for Obesity Indices for Early Detection of Metabolic Syndrome Risk in Taiwanese Adults. [PDF]

Clin Obes
Hsu CY, Guo JW.
europepmc   +1 more source

Machine Learning-Assisted Evaluation of Topography-Dependent Cellular Responses in Meniscus-Mimetic Piezoelectric Nanofibrous Scaffolds. [PDF]

J Funct Biomater
Kim JI, Kim M, Lee S, Lim CH, Choi W, Lee SS.   +5 more
europepmc   +1 more source