Results 91 to 100 of about 828,730 (334)

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Signals on Graphs: Uncertainty Principle and Sampling

open access: yes, 2016
In many applications, the observations can be represented as a signal defined over the vertices of a graph. The analysis of such signals requires the extension of standard signal processing tools.
Barbarossa, Sergio   +2 more
core   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Compressive Signal Processing for Estimating Range-Velocity-AoA in FMCW Radar Applications

open access: yesIEEE Access
Frequency-modulated continuous wave (FMCW) radars are known to accurately estimate the parameters of targets with low-cost and low-power transceiver systems.
Eny Sukani Rahayu   +3 more
doaj   +1 more source

Modified CRLB Based Optimal Sampling Frequency Selection in Phase and Frequency Estimation

open access: yesIEEE Access, 2019
The sampling process is an almost indispensable operation in signal processing. The sampling frequency is one of the factors in the sampling process and the selection of it is also important in the signal processing issues, such as detection, estimation,
Hao Wu, Yongqiang Cheng, Hongqiang Wang
doaj   +1 more source

Sub-Nyquist Sampling: Bridging Theory and Practice [PDF]

open access: yes, 2011
Sampling theory encompasses all aspects related to the conversion of continuous-time signals to discrete streams of numbers. The famous Shannon-Nyquist theorem has become a landmark in the development of digital signal processing. In modern applications,
Eldar, Yonina C., Mishali, Moshe
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Design of signal acquisition system of mine-used electronic belt scale

open access: yesGong-kuang zidonghua, 2015
In view of problems that weighting signal and speed signal of mine-used electronic belt scale has slower speed of signal acquisition and data processing and lower accuracy of data sampling, a design scheme of signal acquisition system of mine-used ...
FAN Lijun, TIAN Bailin
doaj   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

open access: yesFEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche   +2 more
wiley   +1 more source

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