Results 151 to 160 of about 50,799,135 (318)

The mechanism of cellulose hydrolysis by a two-step, retaining cellobiohydrolase elucidated by structural and transition path sampling studies.

Journal of the American Chemical Society, 2014
B. Knott, Majid Haddad Momeni, M. Crowley, L. Mackenzie, Andreas W Götz, M. Sandgren, S. G. Withers, J. Ståhlberg, G. Beckham   +8 more
semanticscholar   +1 more source

Guidelines for the study of the epibenthos of subtidal environments [PDF]

These Guidelines for the Study of the Epibenthos of Subtidal Environments document a range of sampling gears and procedures for epibenthos studies that meet a variety of needs.
Bergman, M.J.N., Birchenough, S.N.R., Boois, I.J., de, Borja, A., Rees, H.L.   +4 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Recruiting data-obscured populations: strategic local government referral sampling for qualitative studies

Humanities & Social Sciences Communications
The research community must develop innovative methodologies that encompass all segments of society in social science research. Undeniably, there are neglected or unidentified sections of society, and including them in research poses challenges. The Gulf
Shinto Joseph, Jasmine Mathew, Joseph Kuncheria   +2 more
doaj   +1 more source

Using data from respondent-driven sampling studies to estimate the number of people who inject drugs: Application to the Kohtla-Järve region of Estonia. [PDF]

PLoS One, 2017
Wu J, Crawford FW, Raag M, Heimer R, Uusküla A.   +4 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Probabilistic Sampling in Media and Communication Studies: Concept, Procedures, and Applications [PDF]

Eon
This study aims to highlight the vital role of sample selection in media and communication research, as it serves as a fundamental tool for saving time, effort, and resources in data collection and analysis.
Brahim DJENNAD, Mokhtar DJELLOULI
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source