Results 91 to 100 of about 526,216 (298)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
, 2007 This paper analyses household unit nonresponse and interviewer effects in six major UK government surveys using a multilevel multinomial modelling approach. The models are guided by current conceptual frameworks and theories of survey participation.
Durrant, Gabriele B., Steele, Fiona
core
European Survey Data on Attitudes to Equality and Human Rights Technical Paper. Research Series [PDF]
, 2019 This report maps the data available on attitudes to equality and human rights issues in Ireland collected in European surveys over the period 2000 to 2018. These surveys provide a rich source of evidence for researchers and policymakers in Ireland.
Fahey, Éamonn +3 more
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
The Relationship between Temperament and Character with Wisdom Through Cognitive Regulation Strategies of Emotion [PDF]
پژوهشنامه روانشناسی مثبتThis study aimed to investigate the relationship between temperament and character and wisdom through the mediation of cognitive-emotion regulation strategies. The research method was descriptive and correlational.
Fahime Naseri, Yasser Azizisaeid
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Bayesian Cosmic Web Reconstruction: BARCODE for Clusters
, 2016 We describe the Bayesian BARCODE formalism that has been designed towards the reconstruction of the Cosmic Web in a given volume on the basis of the sampled galaxy cluster distribution.
Bos, E. G. Patrick +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
, 2011 Discussion of "Impact of Frequentist and Bayesian Methods on Survey Sampling Practice: A Selective Appraisal" by J. N. K. Rao [arXiv:1108.2356]Comment: Published in at http://dx.doi.org/10.1214/11-STS346C the Statistical Science (http://www.imstat.org ...
Slud, Eric
core +1 more source