Results 151 to 160 of about 526,216 (298)

Examining social camouflaging and its cognitive, mental health and neurophysiological correlates in autistic adolescents through triangulation-based assessment using self, parent and daily diary reports: a study protocol. [PDF]

BMJ Open
Klein J, Krahn RL, Howe SJ, Cormier A, Rush J, Ames M, McMorris CA, Macoun S.   +7 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Correction for Participation Bias in Nonprobability Samples Using Multiple Reference Surveys. [PDF]

Stat Med
Landsman V, Wang L, Carrillo-Garcia I, Mitani AA, Smith PM, Graubard BI, Bui T, Carnide N.   +7 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Designing communication strategies to increase rural participation in clinical trials using the Health Belief Model and strategic communication. [PDF]

Contemp Clin Trials Commun
Boatman D, Kennedy-Rea S, Mason J, Thayer J, Reece R, Bailey J, Hansen S, Norton C, McCoy M, Hodder S.   +9 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

The distribution characteristics of medusozoans (Cnidaria) related to environmental factors in cold source water intake area of the Fangchenggang Nuclear Power Plant based on eDNA metabarcoding technology. [PDF]

PeerJ
Su T, Guo J, Xu M, Xie Y, Tan B, Pan H, Tan X, Yi L, Huang L, Lai J.   +9 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Cohort profile: design and respondent characteristics for the longitudinal Survey of Trauma, Resilience and Opportunity Among Neighbourhoods in the Gulf (STRONG) cohort. [PDF]

BMJ Open
Harding AB, Parker AM, Parks V, Seelam R, Atshan S, Dormanesh A, Becker K, Ghosh Dastidar B, Ramchand R, Finucane ML, Slack T, Waldron-Moore PN, Ayer L.   +12 more
europepmc   +1 more source