Results 131 to 140 of about 7,676,917 (278)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Ultrasound imaging of the spinal accessory nerve in the neck. [PDF]

Ultrasound
Fenech M, Appavoo Juhasz K.
europepmc   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Patient perspectives about deployment of artificial intelligence decision support tools in a safety-net healthcare system. [PDF]

JAMIA Open
Phelps N, Vossler P, Kothari A, Steineman K, Goldman S, Gasga A, Ehrlich S, Kanzaria H, Adler-Milstein J, Feng J, Nong P, Zier LS.   +11 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Correction: Informed Consent Practices for Publication of Patient Images in Dermatology Journals. [PDF]

JMIR Dermatol
Taiwo T, Obiakor B, McClung S, Shinkai K.   +3 more
europepmc   +1 more source

'Sans Papiers' sans guillemets

, 2010
Qu'est-ce que c'est qu’un milieu traducteur ? A mon avis, le milieu traducteur est lié à la fonction d'une dynamique sémiotique locale, exprimée par une structure organisée (individu, groupe, communauté) dans laquelle les frontières d'un enregistrement deviennent visibles dans un milieu et communicables comme traduction.
openaire   +1 more source

Sans droits, sans travail, sans logement, sans papiers : des précaires en mouvement

Calenda, 2005
Dans le contexte actuel post 21 avril 2002, s’interroger sur les mobilisations de précaires offre la possibilité pour de jeunes chercheurs mais aussi pour des chercheurs confirmés de redécouvrir les classes populaires, les sans ressources. De plus, les débats sur l’élargissement de l’Union Européenne invitent également les chercheurs à comprendre ce ...
openaire   +1 more source