Results 1 to 10 of about 60 (59)
PLoS ONE, 2023 Due to the increasing level of professionalism, the high frequency of competitions, and the alarming injury rate observed in elite female soccer players, multidisciplinary strategies, including nutritional monitoring, need to be implemented.
Sandra Antón San Atanasio +2 more
doaj +3 more sources
Clinical and Translational Medicine, Volume 13, Issue 4, April 2023., 2023 Activation of WNK1 associates to a worse ovarian cancer patient outcome. WNK1 signals cell proliferation through the ERK5 pathway. Trametinib provokes activation of the WNK1–ERK5 pathway. Combining trametinib with ERK5 route inhibitors may improve patients’ outcome.
Adrián Sánchez‐Fdez +11 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 24, Issue 5, Page 3117-3127, March 2020., 2020 Abstract Identification of druggable vulnerabilities is a main objective in triple‐negative breast cancer (TNBC), where no curative therapies exist. Gene set enrichment analyses (GSEA) and a pharmacological evaluation using a library of compounds were used to select potential druggable combinations.
Verónica Corrales‐Sánchez +8 more
wiley +1 more source
Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects. [PDF]
PLoS ONE, 2012 BackgroundBone loss, in malignant or non-malignant diseases, is caused by increased osteoclast resorption and/or reduced osteoblast bone formation, and is commonly associated with skeletal complications.
Antonio Garcia-Gomez +13 more
doaj +1 more source
Búsqueda, 2014 Uno de los problemas relacionados con la salud presente en nuestras sociedades occidentales es el sobrepeso y la obesidad, para lo cual existen diferentes tipos de dietas y programas de pérdida de peso. Entre ellos, Se ha descrito el uso de dietas de muy
Sandra Antón San Atanasio
doaj +1 more source
Expression of c-Kit isoforms in multiple myeloma: differences in signaling and drug sensitivity
Haematologica, 2008 Background c-Kit is expressed in the plasma cells from 30% of patients with multiple myeloma. Two different isoforms of c-Kit, characterized by the presence or absence of the tetrapeptide sequence GNNK in the extracellular domain, have been described ...
Juan Carlos Montero +3 more
doaj +1 more source
Haematologica, 2012 Although new therapies have doubled the survival of multiple myeloma patients, this remains an incurable disease. It has been postulated that the so-called myeloma cancer stem cells would be responsible for tumor initiation and relapse but their ...
Teresa Paíno +9 more
doaj +1 more source
Cuadernos de Teología - Universidad Católica del Norte, 2016 El I Simposio Patrístico de Antofagasta, espléndidamente organizado por la Dra. Eva Reyes y los miembros del Instituto Superior de Ciencias Religiosas de la Universidad Católica del Norte, Antofagasta, ha sido una oportunidad para diversos estudiosos de ...
Óscar Velásquez
doaj +1 more source
Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Glioblastoma (GBM) is the most common and devastating primary brain tumor. The presence of cancer stem cells (CSCs) has been linked to their therapy resistance. Molecular and cellular components of the tumor microenvironment also play a fundamental role in the aggressiveness of these tumors.
Esther Hernández-SanMiguel +11 more
wiley +1 more source
Deficient spindle assembly checkpoint in multiple myeloma.
PLoS ONE, 2011 Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and ...
Elena Díaz-Rodríguez +7 more
doaj +1 more source