Results 181 to 190 of about 1,323,764 (303)
Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice
Brain Pathology, EarlyView.We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga +11 more
wiley +1 more source
Brain Pathology, EarlyView.A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña +20 more
wiley +1 more source
Chapter F of the International Code of Nomenclature for algae, fungi, and plants as approved by the 11th International Mycological Congress, San Juan, Puerto Rico, July 2018. [PDF]
IMA Fungus, 2019 May TW +6 more
europepmc +1 more source
Child and Adolescent Mental Health, EarlyView.Background Neurodevelopmental disorders like autism and ADHD may disrupt family and child functioning. Although well‐established psychosocial treatment programs exist, access to these interventions remains limited for many families. This randomized controlled trial (RCT) primarily evaluates the effectiveness of an online psychosocial program (INPSYD ...
Ana Pardo‐Salamanca +4 more
wiley +1 more source
Environmental justice in education for climate action: Case studies from Perú and Uganda
Children &Society, EarlyView.Abstract This paper draws on participatory research with secondary school learners in Perú and Uganda that shows how environmental and social (in) justices are interwoven and embedded in young people's experiences of the natural world. These experiences contrast with learners' accounts of environmental education in secondary schooling, in which the ...
Rachel Wilder +3 more
wiley +1 more source
Revealing patterns of endemism in the transatlantic family Chelodesmidae (Polydesmida: Diplopoda)
Cladistics, EarlyView.Abstract With fossil records dating back to the Silurian/Late Ordovician, millipedes stand out as one of the earliest terrestrial animal groups. Their limited vagility and high endemism make them valuable tools for formulating and testing biogeographic hypotheses, including those related to macro‐vicariance events.
Rodrigo Salvador Bouzan +4 more
wiley +1 more source
Differences in characteristics between naturalized threatened plants and other threatened plants
Conservation Biology, EarlyView.Abstract Many non‐native plant species introduced by humans have become naturalized. At the same time many species are threatened in their native range. However, the number of plant species threatened in their native range that are naturalized elsewhere remains unknown.
Weihan Zhao +10 more
wiley +1 more source
Children exposed to alcohol-related problems and DSM-5 alcohol use disorder in San Juan, Puerto Rico. [PDF]
J Ethn Subst Abuse, 2019 Caetano R, Vaeth PAC, Canino G.
europepmc +1 more source