Results 221 to 230 of about 1,356,391 (352)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Children exposed to alcohol-related problems and DSM-5 alcohol use disorder in San Juan, Puerto Rico. [PDF]

J Ethn Subst Abuse, 2019
Caetano R, Vaeth PAC, Canino G.
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Mtro. Rodolfo Antonio San Juan San Juan

, 2017
openaire   +1 more source

Dust Deposited on Snow Cover in the San Juan Mountains, Colorado, 2011–2016: Compositional Variability Bearing on Snow‐Melt Effects

, 2020
Richard L. Reynolds, Harland L. Goldstein, Bruce M. Moskowitz, Raymond F. Kokaly, Seth M. Munson, Peat Solheid, George N. Breit, C. R. Lawrence, Jeff Derry   +8 more
openalex   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Meteorologically Driven Simulations of Dengue Epidemics in San Juan, PR. [PDF]

PLoS Negl Trop Dis, 2015
Morin CW, Monaghan AJ, Hayden MH, Barrera R, Ernst K.   +4 more
europepmc   +1 more source

Variations in Natural Gas Composition in Blanco Field, San Juan Basin, Related to Source-Rock Type, Thermal Maturity, and Migration: ABSTRACT

, 1976
Duane H. Buckner
openalex   +1 more source

Environmental justice in education for climate action: Case studies from Perú and Uganda

Children &Society, EarlyView.
Abstract This paper draws on participatory research with secondary school learners in Perú and Uganda that shows how environmental and social (in) justices are interwoven and embedded in young people's experiences of the natural world. These experiences contrast with learners' accounts of environmental education in secondary schooling, in which the ...
Rachel Wilder, Expedito Nuwategeka, Carlos Monge, Alithu Bazan Talavera   +3 more
wiley   +1 more source