Results 201 to 210 of about 454,361 (299)

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in Caenorhabditis elegans. [PDF]

Nat Prod Bioprospect
Romussi S, Lacour A, Rayes D, De Rosa MJ.   +3 more
europepmc   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

WABAD: A world annotated bird acoustic dataset for passive acoustic monitoring. [PDF]

Ecology
Pérez-Granados C, Morant J, Darras KFA, Marín-Gómez OH, Mendoza I, Muñoz-Mohedano MA, Santamaría-García E, Bastianelli G, Márquez-Rodríguez A, Budka M, Bota G, De la Peña-Rubio JM, de la Morena ELG, Santa-Cruz M, de la Nava P, Fernández-Tizón M, Sánchez-Mateos H, Barrero A, Traba J, Osiejuk TS, Hart PJ, Navine AK, Montoya Muñoz AF, de Araujo CB, Rosa GLM, Denóbile Torres IM, Camargo Catalano AL, Simões CR, Llusia D, Morales MB, Acebes P, Medina JA, Brown N, Astaras C, Karmiris I, Navarrete E, Cauchoix M, Barbaro L, Funosas D, Arend D, Müeller S, González-García F, González-Romero A, Mammides C, Pontikis M, Jacuzzi G, Olden JD, Bombaci SP, Marcacci G, Jacot A, Zurano JP, Gangenova E, Varela D, Di Sallo F, Zurita GA, Atemasov A, Tremblay JA, Lamarre V, Hutschenreiter A, Monroy-Ojeda A, Díaz-Vallejo M, Chaparro-Herrera S, Briers RA, Sousa-Lima R, Pinheiro T, da Silva WC, Calvente A, Molin AD, Antonelli A, Gogoleva S, Palko I, Trọng HV, Lage Duarte MH, Dos Santos Saturnino N, Silva SR, Rainho A, Lopes P, Schuchmann KL, Marques MI, de Oliveira AS, Littlewood NA, Tuanmu MN, Cheng YR, Chao H, Kepfer-Rojas S, Aguilera AL, Brotons L, Feldman MJ, Imbeau L, Panwar P, Weed AS, Deshwal A, da Paz RV, Salustio-Gomes C, Oliveira-Júnior DD, Lima-Santos CS, Pichorim M, Pan W, Goodale E, Attisano A, Theuerkauf J, Sebastián-González E.   +101 more
europepmc   +1 more source

Sexo, Género y Pedagogía análisis de las prácticas pedagógicas en ciclo IV del Colegio Juan Rey IED, San Cristóbal Sur, Bogotá.

, 2017
Esta investigación se desarrolla en el campo educativo, tiene como objetivos identificar y analizar las formas de producción y reproducción del sistema de sexo-género subyacente a las prácticas pedagógicas de: la participación, el seguimiento-control, la evaluación y el descanso en los escenarios del patio y el aula escolar en ciclo IV, del colegio ...
openaire   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Acromegalic features and hypoglycemia: Doege-Potter syndrome. [PDF]

Caspian J Intern Med
Paz-Ibarra J, Silvestre HH, Lúcar Siu GA, Del Carpio Reymer G, Cubas Llalle W, Concepción-Zavaleta M, Concepción-Urteaga L, Quiroz-Aldave JE, Arzapalo Benavides J, Somocurcio Peralta J.   +9 more
europepmc   +1 more source

Environmental justice in education for climate action: Case studies from Perú and Uganda

Children &Society, EarlyView.
Abstract This paper draws on participatory research with secondary school learners in Perú and Uganda that shows how environmental and social (in) justices are interwoven and embedded in young people's experiences of the natural world. These experiences contrast with learners' accounts of environmental education in secondary schooling, in which the ...
Rachel Wilder, Expedito Nuwategeka, Carlos Monge, Alithu Bazan Talavera   +3 more
wiley   +1 more source

Advancing the design of the kissing bug kill trap for surveillance of triatomines. [PDF]

PLoS Negl Trop Dis
Tian Y, Fernández-Santos NA, Juarez JG, Esquivel H, Moller-Vasquez AM, Granados-Presa M, Echeverria A, Pennington P, Zamora-Jerez A, Fimbres-Macias JP, Roachell W, Lenhart PA, Casey T, Keck ME, Hodo CL, Downs CH, Sittenauer SC, Nevins CC, Balasubramanian S, Angulo C, Palacios-Cardiel C, Gaxiola-Robles R, Zenteno-Savín T, Hamer SA, Borden JH, Banfield MG, Padilla N, Hamer GL.   +27 more
europepmc   +1 more source

The collective application of shorebird tracking data to conservation

Conservation Biology, EarlyView.
Abstract Addressing urgent conservation issues, such as the drastic declines of North American migratory birds, requires creative, evidence‐based, efficient, and collaborative approaches. The abundance of over 50% of monitored North American shorebird populations has declined by over 50% since 1980. To address these declines, we developed a partnership
Autumn‐Lynn Harrison, Candace Stenzel, Alexandra Anderson, Jessica Howell, Richard B. Lanctot, Marley Aikens, Joaquín Aldabe, Liam A. Berigan, Joël Bêty, Erik Blomberg, Juliana Bosi de Almeida, Andy J. Boyce, David W. Bradley, Stephen Brown, Jay Carlisle, Edward Cheskey, Katherine Christie, Sylvain Christin, Rob Clay, Ashley Dayer, Jill L. Deppe, Willow English, Scott A. Flemming, Olivier Gilg, Christine Gilroy, Susan Heath, Jason M. Hill, J. Mark Hipfner, James A. Johnson, Luanne Johnson, Bart Kempenaers, Paul Knaga, Eunbi Kwon, Benjamin J. Lagassé, Jean‐François Lamarre, Christopher Latty, Don‐Jean Léandri‐Breton, Nicolas Lecomte, Pam Loring, Laura A. McDuffie, Rebecca McGuire, Scott Moorhead, Juan G. Navedo, David Newstead, Erica Nol, Alina Olalla‐Kerstupp, Bridget Olson, Elizabeth Olson, Julie Paquet, Allison K. Pierce, Jennie Rausch, Kevin Regan, Matthew E. Reiter, Amber M. Roth, Mike Russell, Daniel Ruthrauff, Sarah T. Saalfeld, Amy L. Scarpignato, Shiloh Schulte, Nathan R. Senner, Joseph A. M. Smith, Paul A. Smith, Zach Spector, Kelly Srigley Werner, Michelle L. Stantial, Audrey R. Taylor, T. Lee Tibbitts, Mihai Valcu, Nils Warnock, Walter Wehtje, Brad Winn, Michael B. Wunder   +71 more
wiley   +1 more source