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Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System

Annals of Neurology, Volume 100, Issue 4, Page 709-736, October 2026.
Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti +17 more
wiley +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk

Annals of Neurology, Volume 100, Issue 4, Page 737-750, October 2026.
Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber +24 more
wiley +1 more source

Health System Factors in Head and Neck Cancer Diagnosis: A HEADSpAcE Consortium Qualitative Study in Glasgow and Montevideo

Head &Neck, Volume 48, Issue 10, Page 2849-2862, October 2026.
ABSTRACT Background Head and neck cancer (HNC) is a devastating diagnosis, with advanced‐stage disease leading to poorer outcomes. This qualitative study aimed to identify health system factors associated with stage of HNC diagnosis. Methods Qualitative semistructured interviews with HNC patients and clinicians were undertaken in two purposively ...
Grant Creaney +196 more
wiley +1 more source

Preharvest supplemental lighting enhances productivity and modulates postharvest quality in hydroponically grown Apulian unripe melon ‘Scopatizzo’ ( Cucumis melo L.)

Journal of the Science of Food and Agriculture, Volume 106, Issue 13, Page 7666-7681, October 2026.
Abstract BACKGROUND Preharvest light management is increasingly used to enhance yield and fruit quality in soilless systems, yet its effects on unripe melon fruits remain poorly understood. This study evaluated the impact of supplemental red–blue light‐emitting diode (LED) lighting applied during cultivation in a closed‐cycle hydroponic system on ...
Onofrio Davide Palmitessa +7 more
wiley +1 more source

Intermittent cocaine use patterns, not total intake, predict cue‐induced drug seeking in rats

British Journal of Pharmacology, Volume 183, Issue 20, Page 6094-6112, October 2026.
Abstract Background and Purpose Cocaine‐associated cues trigger relapse to drug use in humans and animal models. In rats, long daily cocaine access (4–6 vs. 1–2 h) increases drug self‐administration and cue‐induced cocaine seeking, suggesting that greater intake promotes relapse.
Amélie Mainville‐Berthiaume +6 more
wiley +1 more source

Genetic landscape of a neonatal hypogonadotropic hypogonadism series: Novel variants and phenotypic spectrum

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract To describe clinical presentation and genetic findings in a cohort of infants with congenital hypogonadotropic hypogonadism (CHH) diagnosed before 2 years of age. From a large cohort of patients who underwent next‐generation sequencing (NGS) for CHH between 2019 and 2025, we identified all patients tested at ≤2 years of age.
Karine Aouchiche +16 more
wiley +1 more source

Ectomycorrhizal Cortinariaceae species dominate class II peroxidase gene expression in a boreal forest soil

New Phytologist, Volume 252, Issue 1, Page 400-413, October 2026.
Share of transcripts and ITS2 sequence for each gene families among identified fungal contigs and OTUs. Summary Boreal forest ecosystems constitute a large terrestrial reservoir of carbon. In these nitrogen‐limited environments, release of nutrients through decomposition of soil organic matter is of fundamental importance.
Florian Barbi +4 more
wiley +1 more source

Shallow Landslides Align With Atmospheric Rivers in Coastal Steeplands

Geophysical Research Letters, Volume 53, Issue 18, 28 September 2026.
Abstract Rapid, shallow landslides in coastal mountains are triggered by extreme precipitation, shaping topography and impacting human settlements. Using an inventory of >700 landslides mapped from satellite imagery (2009–2024) and an atmospheric river database (1981–2019), this study documents linkages between climatic drivers and the topographic ...
Joshua J. Roering +13 more
wiley +1 more source

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen +5 more
wiley +1 more source

Microscopic Insights into Magnetic Warping and Time‐Reversal Symmetry Breaking in Topological Surface States of Rare‐Earth‐Doped Bi2Te3

Advanced Materials, Volume 38, Issue 51, 11 September 2026.
Magnetic doping of the topological insulator Bi2Te3 with erbium adatoms induces out‐of‐plane magnetism and breaks time‐reversal symmetry, opening a Dirac gap and driving a Fermi surface transition from hexagonal to star‐of‐David geometry. Microscopy, spectroscopy, and magnetic dichroism reveal atomically controlled magnetic interactions that tailor the
Beatriz Muñiz Cano +18 more
wiley +1 more source

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