Results 61 to 70 of about 2,308,363 (301)
Advanced Science, EarlyView.Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai +15 more
wiley +1 more source
Assessment and mitigation strategies to counteract overheating in urban historical areas in Rome [PDF]
, 2018 As urban overheating is increasing, there is a strong public interest towards mitigation strategies to enhance comfortable urban spaces, for their role in supporting urban metabolism and social life.
Battisti, Alessandra +2 more
core +2 more sources
Advanced Science, EarlyView.A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun +23 more
wiley +1 more source
A Commentary on Litigation Involving Uber Technologies, Inc. [PDF]
, 2018 Uber Technologies, Inc. is a peer-to-peer ridesharing, food delivery, and transportation network managed in San Francisco, California. Travis Kalanick and Garrett Camp developed the idea for the ridesharing app in 2008, after experiencing difficulty ...
Hagemeier, Catherine
core +2 more sources
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Advanced Science, EarlyView.In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
PLoS ONE, 2018 BackgroundInitiated in 2016, End Hep C SF is a comprehensive initiative to eliminate hepatitis C (HCV) infection in San Francisco. The introduction of direct-acting antivirals to treat and cure HCV provides an opportunity for elimination.
Shelley N Facente +11 more
doaj +1 more source
A Survey of Viva CalleSJ Participants: San Jose, California 2015 [PDF]
, 2016 This report presents the findings from a survey of participants at the Viva CalleSJ open streets event held on October 11, 2015. The survey was designed to provide information that would help the City of San Jose assess the success of the event, guide ...
Agrawal, Asha W., Nixon, Hilary
core +2 more sources
Molecular analysis of endocrine disruption in hornyhead turbot at wastewater outfalls in southern california using a second generation multi-species microarray. [PDF]
, 2013 Sentinel fish hornyhead turbot (Pleuronichthysverticalis) captured near wastewater outfalls are used for monitoring exposure to industrial and agricultural chemicals of ~ 20 million people living in coastal Southern California.
Angert, Mila +15 more
core +2 more sources
RETREG1‐Mediated Reticulophagy is Essential for Dendritic Cell Maturation and Function in Sepsis
Advanced Science, EarlyView.Reticulophagy regulator 1 (RETREG1) maintains dendritic cell (DC) maturation and function in early sepsis. Mechanistically, activating transcription factor 6 (ATF6) acts as a direct transcription factor regulating RETREG1 expression in response to sepsis‐induced endoplasmic reticulum (ER) stress.
Ren‐Qi Yao +28 more
wiley +1 more source
Spatial planning and architectural innovation in the Roman town of Ocriculum. [PDF]
, 2018 The Roman settlement of Ocriculum (Otricoli, TR - Umbria), built on a tufa slope between the Tiber valley to the north and the San Vittore valley to the south, was established on massive substructures, which allowed the exploitation of a larger area ...
ANTONELLI, GIACOMO
core +1 more source