Results 71 to 80 of about 4,099 (263)

الجزاءات الإدارية: بين ضرورات الفعالية الإدارية وقيود حماية الحقوق والحريات الأساسية -دراسة مقارنة -

مجلة الآداب و العلوم الإجتماعية, 2014
in each system of law, the administrative sanctions take a distinct place along the criminal and civil sanctions. Administrative sanctions are inflicted by administrative bodies to ensure the fulfillment of certain obligations or restoring some legal ...
صلاح الدين بوجلال
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Le juge administratif et les autorités de régulation au Maroc, quel rapport ?

Geopolitic and Geostrategic Intelligence
Résumé : L’émergence des autorités de régulation constitue l’une des transformations majeures de l’action administrative contemporaine. Investies de pouvoirs normatifs, de contrôle et parfois de sanction dans des secteurs économiques et sociaux ...
Professeur Morad El ABBASSI, Doctorant Ilias AIT MAASSI
doaj   +1 more source

NATIONAL COUNCIL FOR COMBATING DISCRIMINATION – COURT OF JUSTICE OF EUROPEAN UNION – BUCHAREST COURT OF APPEAL. CAUSE C-81/12 [PDF]

Challenges of the Knowledge Society, 2014
The scope of this investigation consists in closing the jurisdictional circle initiated in 2010 and analysing the national and European procedural, jurisdictional-administrative issues, in case of notifying some institutions related to certain ...
Cristian JURA
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

LEGAL STATUS AND ACTIVITIES OF BODIES AUTHORISED TO IMPOSE FINANCIAL ADMINISTRATIVE SANCTIONS

Baltic Journal of Economic Studies
The existence of a system of financial liability measures is a common occurrence in market economies. Despite their considerable motivational potential, financial administrative sanctions constitute a significant interference with human rights ...
Tetiana Kolomoiets, Serhii Kushnir, Ivan Shumeiko   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pertanggungjawaban Pidana Bank dalam Pelanggaran Kegiatan Operasional Didasarkan pada Undang-Undang Nomor 10 Tahun 1998

Dialogia Iuridica, 2017
Banks are the intermediation institutions which have important role in economic of a nation. In order to supervise and monitor bankong activities, government has issued Law Number 10 of 1998 on amandement of Law Number 7 of 1992 on banking which is ...
Johannes Ibrahim, Hassanain Haykal
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source