Results 161 to 170 of about 351,889 (302)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken   +8 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

open access: yesAdvanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan   +7 more
wiley   +1 more source

Cryo‐EM and NMR Reveal a Membrane‐Gated Doc2B–Munc13‐1 Complex and a Helical Doc2B‐SNARE‐Binding Interface

open access: yesAdvanced Science, EarlyView.
Biophysical studies of Doc2B yield a cryo‐electron microscopy structure of its complex with the synaptic vesicle priming factor Munc13‐1 and its binding site to the SNARE complex that mediates synaptic vesicle fusion. These and other results suggest a novel model whereby Doc2 proteins regulate neurotransmitter release through sequential interactions ...
Cyrus T. Rastegar   +8 more
wiley   +1 more source

On Local Instability of Deep-Profiled Facings in Sandwich Panels. [PDF]

open access: yesMaterials (Basel)
Pozorski Z   +3 more
europepmc   +1 more source

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