Results 41 to 50 of about 351,889 (302)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Modelling of low-energy/low-velocity impact on Nomex honeycomb sandwich structures with metallic skins [PDF]

, 2008
In the aircraft industry, manufacturers have to decide quickly whether an impacted sandwich needs repairing or not. Certain computation tools exist at present but they are very time-consuming and they also fail to perfectly model the physical phenomena ...
Thevenet, P., Barrau, J.-J. J.-J., Castanié, Bruno, J.-J. Barrau, C. Bouvet, B. Castanié, Barrau, Jean-Jacques, Bouvet, Christophe, P. Thevenet, Aminanda, Y., Y. Aminanda, Aminanda, Yulfian, Thévenet, Pascal   +12 more
core   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Multiscale Approach for the Design of Composite Sandwich Elements [PDF]

, 2010
In the present work, composite sandwich components, that perfectly match the challenging demands of lightweight and more customized structures, have been characterized and designed as a roof panels of a railway vehicle.
Zinno, Alberto
core   +1 more source

An Investigation of Lightly Profiled Sandwich Panels subject to Local Buckling and Flexural Wrinkling Effects [PDF]

, 2005
Sandwich panels exhibit various types of failure modes depending on the steel face used. For the flat and lightly profiled sandwich panels, flexural wrinkling is an extremely important design criterion as the behaviour of these panels is governed mainly ...
Mahendran, Mahen, Pokharel, Narayan D.
core   +2 more sources

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Design and commission of an experimental test rig to apply a full-scale pressure load on composite sandwich panels representative of aircraft secondary structure

, 2009
This paper describes the design of a test rig, which is used to apply a representative pressure load to a full-scale composite sandwich secondary aircraft structure.
Crump, D.A., Savage, J., Dulieu-Barton, J.M., J M Dulieu-Barton, J Savage, D A Crump   +5 more
core   +1 more source

Fabrication and mechanical testing of glass fiber entangled sandwich beams: A comparison with honeycomb and foam sandwich beams [PDF]

, 2009
The aim of this paper is the fabrication and mechanical testing of entangled sandwich beam specimens and the comparison of their results with standard sandwich specimens with honeycomb and foam as core materials.
Bouvet, Christophe, Morlier, Joseph, Gourinat, Yves, Shahdin, Amir, Mezeix, Laurent   +4 more
core   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source