Development of a Novel Sandwich ELISA Test for the Detection of Antibodies Against Rickettsia. [PDF]
PathogensQuevedo-Diaz M +4 more
europepmc +1 more source
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
Free Vibration Analysis of Thin Functionally Graded Plate Bands with Microstructure as a Function of Material Inhomogeneity Distribution and Boundary Conditions. [PDF]
Materials (Basel)Jędrysiak J, Kaźmierczak-Sobińska M.
europepmc +1 more source
Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics
Advanced Science, EarlyView.Integrated computational‐biological programming enables secure in vivo data storage by generating code tables from either genomes or gene regulatory networks, expanding the encryption key space by over 100 orders of magnitude. Storing code tables within synthetic genes, genomes, or gene regulatory networks adds an additional layer of security by ...
Jiaxin Xu +9 more
wiley +1 more source
Recruiting ESCRT to single-chain heterotrimer peptide MHCI releases antigen-presenting vesicles that stimulate T cells selectively. [PDF]
Proc Natl Acad Sci U S AOlson BA +6 more
europepmc +1 more source
Super‐Robust Telecommunications Enabled by Topological Half‐Supermodes
Advanced Science, EarlyView.Through topological half‐supermode engineering, we realize a valley‐ridge gap waveguide that is directly compatible with conventional waveguides and features topological protection. This design halves the lateral size via a PEC boundary, enabling direct TE₁₀‐mode matching and robust bend‐immune transmission.
Rui Zhou +8 more
wiley +1 more source
Free and Transient Vibration Analysis of Sandwich Piezoelectric Laminated Beam with General Boundary Conditions. [PDF]
Materials (Basel)Zhang X +6 more
europepmc +1 more source
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Experimental research on the fire resistance of columns in container-style steel modular buildings. [PDF]
Sci RepDuan J, Liu J, Wei J, Wu H, Gao S.
europepmc +1 more source
Peptide Sequence Programmed Piezoelectric Response by Supramolecular Self‐Assembly
Advanced Science, EarlyView.In this study, hydrophobic tripeptides are explored as building blocks for stable piezoelectric crystals. Tripeptides with phenylalanine at the central position self‐assembled into uniform, thermally stable crystals. Piezoresponse force microscopy reveals a high effective piezoelectric coefficient of 24.0 pC N−1, attributed to asymmetric molecular ...
Xuejiao Yang +6 more
wiley +1 more source