Epilepsia, EarlyView.Abstract Seizure frequency has been the primary endpoint in epilepsy trials, with enrollment usually requiring ≥4 seizures per month. This threshold is more and more misaligned with clinical reality, as the availability of more treatment options has reduced baseline seizure burden, with a risk of excluding a proportion of patients from trials. Although
Stéphane Auvin, Jacqueline French
wiley +1 more source
Epilepsia, EarlyView.On day 0 adult male and female rats were injected with Stable Substance P‐Saporin (SSP‐SAP) at 4 unilateral sites along the longitudinal axis of the dentate gyrus. Rats exhibited spontaneous electrographic and behavioral reactive seizures between days 4‐6. There was a progressive loss of CA1 and CA3 neurons and a progressive increase in astrocytes over
Srijal Gupta +4 more
wiley +1 more source
An unusual case of diffuse glabrous skin dermatophytosis caused by <i>Trichophyton tonsurans</i> in a limited-resource setting: A case report. [PDF]
IDCasesYerbanga IW +9 more
europepmc +1 more source
Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy
Epilepsia, EarlyView.Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger +10 more
wiley +1 more source
An algorithm for seizure detection in rodents
Epilepsia Open, EarlyView.Abstract Objective Epilepsy animal research often relies on long‐term intracranial electroencephalographic (iEEG) recordings. Here, we describe an artificial neural network (ANN) algorithm for automatic detection of seizures. Methods The algorithm was trained on iEEG recordings of three mouse models of chronic epilepsy: (1) the pilocarpine model of ...
Lyna Kamintsky +9 more
wiley +1 more source
Detection of focal impaired awareness seizures using a biometric shirt
Epilepsia Open, EarlyView.Abstract Objective In recent years, seizure detection using wearable technology has gained significant attention in research. Most studies, however, have focused on detecting generalized or focal to bilateral tonic–clonic seizures. This study evaluates the feasibility of using a biometric shirt to detect focal impaired awareness seizures (FIAS) by ...
Jérôme St‐Jean +6 more
wiley +1 more source
Les inégalités écologiques à l’aune du choléra : étude dans la ville de Cotonou au Bénin
Carnets de Géographes, 2017 Taofick Raoul Fousséni
doaj +1 more source
Smoking and social inequalities in France, 20 years of evolution: A secondary dataset analysis of health barometers. [PDF]
Tob Induc DisPasquereau A +4 more
europepmc +1 more source
Ketogenic diet for infantile epileptic spasms
Epilepsia Open, EarlyView.Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury +3 more
wiley +1 more source
Les rassemblements de masse mettent en évidence de graves vulnérabilités dans la capacité du système de santé canadien. [PDF]
CMAJVarner C.
europepmc +1 more source