Results 51 to 60 of about 5,527 (138)
Exact Randomized Two‐Stage Phase 2 Clinical Trial Designs for Two Binary Co‐Primary Endpoints
Statistics in Medicine, Volume 45, Issue 3-5, February 2026.ABSTRACT Phase 2 clinical trials typically rely on a single primary endpoint, yet in many settings, treatment efficacy must be demonstrated across multiple co‐primary endpoints. Such settings require intersection‐union hypothesis testing, in which the global null hypothesis is rejected only when all individual component hypotheses are rejected ...
Hyejung Jung +3 more
wiley +1 more source
Journal of Sleep Research, Volume 35, Issue 1, February 2026.ABSTRACT Patients with insomnia face difficult decisions when choosing between treatment options with competing risk–benefit profiles. Patient treatment choices were evaluated as part of a pragmatic nonrandomized clinical trial for a two‐step cognitive behavioural therapy for insomnia (CBT‐I) intervention. Upon enrollment, participants were guided by a
Janet M. Y. Cheung +4 more
wiley +1 more source
Revue des Sciences de la SantéLa santé mentale des adolescents et des jeunes constitue un enjeu majeur de santé publique à l’échelle mondiale. La tranche d’âge de 12 à 24 ans représente une période critique de transition marquée par des transformations biologiques, psychologiques et ...
John MUSENGA TSHIBANGU +2 more
doaj +1 more source
Infant Mental Health Journal: Infancy and Early Childhood, Volume 47, Issue 1, January 2026.Abstract Infant‐directed singing (IDSi) is a natural means of dyadic communication that contributes to children's mental health by enhancing emotion expression, close relationships, exploration and learning. Therefore, it is important to learn about factors that impact the IDSi.
Raija‐Leena Punamäki +3 more
wiley +1 more source
Sociologie clinique et santé mentale
Sociedade e EstadoRésumé Le projet “Rétablissement et projet de vie” a un double objectif: i. proposer aux intervenants et aux résidents de la Maison Saint-Dominique (MSD - Montréal/Canada), un travail approfondi sur leur “roman familial et trajectoire sociale”, dans l ...
Vincent de Gaulejac, Diane Laroche
doaj +1 more source
Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb
Nature Communications, 2016 The mechanism by which adult-born neurons quickly adjust olfactory bulb network functioning is not understood. Here the authors describe a novel form of structural plasticity in which mature spines relocate toward active mitral cell dendrite along spine ...
Vincent Breton-Provencher +8 more
doaj +1 more source
Extension of the Generalized Disequilibrium Test to polytomous phenotypes and two-locus models
Frontiers in Genetics, 2014 We extend the usual logistic model between a dichotomous phenotype and an allele count in two ways: a polytomous phenotype with K > 2 levels, and modelling of allele counts at two unlinked marker loci.
Alexandre eBureau +7 more
doaj +1 more source
Lorazepam-Resistant Catatonia in an Antipsychotic-Naïve 24-Year-Old with Psychotic Symptoms
Case Reports in Psychiatry, 2020 Catatonia is a complex identifiable clinical syndrome characterized primarily by psychomotor symptoms. In recent decades, some authors have considered that catatonia can be presented as a catatonic syndrome in several pathologies such as bipolar disorder,
Juan Pablo Lucchelli +3 more
doaj +1 more source
Distribution of vesicular glutamate transporters in the human brain
Frontiers in Neuroanatomy, 2015 Glutamate is the major excitatory transmitter in the brain. Vesicular glutamate transporters (VGLUT1-3) are responsible for uploading glutamate into synaptic vesicles.
Erika eVigneault +13 more
doaj +1 more source
SOMATOTOPIC ORGANIZATION OF FERRET THALAMUS
Frontiers in Integrative Neuroscience, 2014 The stereotaxic reference marks of ferret skull have large variability and the reference point for stereotaxic experiments in ferret brain is difficult to define.
Mario eVázquez García +4 more
doaj +1 more source