Results 91 to 100 of about 857,975 (310)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Desarrollo de psoriasis durante el tratamiento con Abatacept en artritis reumatoidea

Revista Argentina de Reumatología, 2019
Abatacept es el primer agente biológico aprobado para el tratamiento de la Artritis Reumatoidea (AR) que actúa inhibiendo la co-estimulación de linfocitos T.
J.A. Riera, J.A. Riera, J.L. Musuruana, C.A. Costa, J.A. Cavallasca   +4 more
doaj   +1 more source

Investigación Orientada Santa Fe

, 2021
Fil: Svampa, Fernando. Univerisidad Nacional de Río Negro. Instituto de Estudios en Ciencia, Tecnología, Cultura y Desarrollo. Río Negro; Argentina.
Bercovich, Bárbara, Bustamante, María Carolina, Fiorentin, Florencia, Montesino, Gaston Federico, Svampa, Fernando   +4 more
openaire   +1 more source

A Fully Coupled Formulation For Incompressible Fluid-Elastic Structure-Interactions [PDF]

, 2005
We present a general formulation for analysis of fluid flows with structural interactions using the particle finite element method (PFEM). The fluids are fully coupled to the structures that can undergo highly non-linear response due to large ...
Idelsohn, Sergio Rodolfo, Limache, Alejandro Cesar, Marti, Julio Marcelo   +2 more
core  

Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody‐Mediated Thrombotic Disorders

Advanced Science, EarlyView.
A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar, Adam Kanack, Seonhwa Lee, Alan M. Gonzalez‐Suarez, Kihak Gwon, Emily Mauch, Thi Thanh‐Qui Nguyen, Anand Padmanabhan, Alexander Revzin   +8 more
wiley   +1 more source

Depression and microvascular complications predict poor goal achievement among Colombian patients with type 2 diabetes

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2017
Aims: Many patients with type 2 diabetes (DM2) in Latin American countries remain insufficiently controlled. We aimed to identify factors associated with persistent poor metabolic control in Colombian patients with DM2.
Catalina Sanmiguel, María C. Luna, William Kattah, Carlos O. Mendivil   +3 more
doaj   +1 more source

Endoscopic Retrograde Cholangiopancreatography in Children: Nine Years' Experience at Santa Fe Foundation in Bogota, Colombia. [PDF]

Cureus, 2023
Gómez SR, Trujillo Ceballos AA, Montaño Rozo GA, Solano Mariño J, Carias Domínguez AM, Vera Chamorro JF.   +5 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Caracterización clínica e histopatológica de niños con hepatitis autoinmune en un centro de referencia de Bogotá, Colombia

Revista Colombiana de Gastroenterología, 2019
La hepatitis autoinmune (HAI) es una enfermedad hepática inflamatoria progresiva poco frecuente en niños y adolescentes, la cual es un reto diagnóstico para clínicos y patólogos.
David A. Suarez-Zamora, Rafael E. Andrade-Perez, Jose F. Vera-Chamorro, Rocio Lopez-Panqueva   +3 more
doaj   +1 more source

Proceedings of the 2023 Santa Fe Bone Symposium: Progress and Controversies in the Management of Patients with Skeletal Diseases. [PDF]

J Clin Densitom, 2023
Lewiecki EM, Bellido T, Bilezikian JP, Brown JP, Farooki A, Kovacs CS, Lee B, Leslie WD, McClung MR, Prasarn ML, Sellmeyer DE.   +10 more
europepmc   +1 more source