Results 61 to 70 of about 48,995 (266)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Abordaje posterior extraseroso de Ochsner

Revista Colombiana de Cirugía, 2002
Objetivo: Mostrar la experiencia en la Fundación Santa Fe de Bogotá con el abordaje extraseroso con resección de la duodécima costilla para el drenaje de los abscesos subfrénicos.
Manuel Cadena, Diego Triviño, Eduardo Londoño, Ricardo Nassar, Roosevelt Fajardo, Carlos Garavito, Fredy Pineda   +6 more
doaj  

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Light‐Controlled Modulation of 15‐Lipoxygenase‐1 Regulates Intestinal Inflammatory Signaling

Angewandte Chemie, EarlyView.
The developed target‐guided strategy enables the rational design of diazo‐based photoswitchable inhibitors of 15‐lipoxygenase‐1. Distinct molecular architectures program opposite light‐dependent activity, allowing on‐demand control of enzyme inhibition.
Anastasia Louka, Eirini‐Eleni Kalaitzaki, Athanasios Panousis, Sotirios Bonoras, Charalampos Livas, George Froudakis, Ioannis Drygiannakis, Athina Damianaki, George Kolios, Vassilis Valatas, Nikolaos Eleftheriadis   +10 more
wiley   +2 more sources

RELACIONES ENTRE ESQUEMAS TEMPRANOS INADAPTADOS Y AFECTIVIDAD POSITIVA Y NEGATIVA

Ciencias Psicológicas, 2015
Este trabajo tuvo como objetivo establecer posibles correlaciones entre los esquemas tempranos inadaptados propuestos por Jeffrey Young y la afectividad positiva y negativa.
Andrés Fernando López Pell, Juan Manuel Rondón, Silvina M. Alfano, Cecilia Cellerino   +3 more
doaj   +1 more source

Longitudinal Single‐Axon‐Resolution Imaging of Peripheral Nerve Injury Response in Mice Using an Optical Window Implant

Advanced Science, EarlyView.
A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky, Emma Anisman, Ron Perez, Sophia Zhang, Morgan Hoffman, Daniel Hunter, Abigail Cherian, Jevon Bonner, Emilia Feria, Ahmed Ahmed, Muneeb Malik, Junwei Du, Leland C. Sudlow, David M. Brogan, Matthew D. Wood, Mikhail Y. Berezin   +15 more
wiley   +1 more source

Glucosinolate and Isothiocyanate Profiles in Different Varieties of Raphanus sativus Seed via Multivariate Data Analysis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Through HPLC–MS/MS analysis and multivariate statistics, raphani semen (RS) varieties with high functional components were screened. The white raphani semen “Xuebawang” was identified as ideal for further study due to its high bioactive content: glucoraphenin (9010.27 mg/100 g), glucoraphanin (1027.76 mg/100 g), sulforaphane (66.14 mg/100 g), and ...
Yonghua Li, Dongmei Lin, Peng Wu, Rui Gao, Jingxiu Bi, Yuying Jiang, Tong Zhao, Xuexia Yuan, Jianhan Xu, Pingxiang Liu, Yutao Wang   +10 more
wiley   +1 more source

El capital psíquico a través del ciclo vital adulto

Avances en Psicología Latinoamericana, 2010
El presente trabajo estudió, en una muestra de 614 sujetos de ambos sexos de la Ciudad de Santa Fe (Argentina), el capital psíquico, definido como el conjunto e interrelación de fortalezas de carácter personal (es decir, recursos cognitivos, emocionales ...
Alexis M. Kasanzew, Andrés F. López Bell, Luciana Brasca, Lucía Legé, Laura S. Casablanca   +4 more
doaj  

Desarrollo de psoriasis durante el tratamiento con Abatacept en artritis reumatoidea

Revista Argentina de Reumatología, 2019
Abatacept es el primer agente biológico aprobado para el tratamiento de la Artritis Reumatoidea (AR) que actúa inhibiendo la co-estimulación de linfocitos T.
J.A. Riera, J.A. Riera, J.L. Musuruana, C.A. Costa, J.A. Cavallasca   +4 more
doaj   +1 more source

Endoscopic Retrograde Cholangiopancreatography in Children: Nine Years' Experience at Santa Fe Foundation in Bogota, Colombia. [PDF]

Cureus, 2023
Gómez SR, Trujillo Ceballos AA, Montaño Rozo GA, Solano Mariño J, Carias Domínguez AM, Vera Chamorro JF.   +5 more
europepmc   +1 more source