DNAJC13 Variants Show No Robust Association With Parkinson's Disease in a Multiancestry Cohort
Abstract Background DNAJC13 was initially linked to autosomal dominant (AD) Parkinson's disease (PD) in a European Mennonite family carrying the p.N855S variant. However, imperfect segregation and conflicting reports of pathogenicity raised uncertainty of the role of DNAJC13 in the disease.
César Luis Ávila +11 more
wiley +1 more source
Mst1 participates in the progression of severe acute pancreatitis-induced intestinal barrier dysfunction via inhibiting autophagy and enhancing apoptosis. [PDF]
Zhang R +6 more
europepmc +1 more source
ABSTRACT The design of control systems for high‐agility mechanical systems operating in extreme environments is a significant challenge in nonlinear dynamics. This paper addresses the complex dynamic control problem of a hypersonic interceptor, modeled as a multi‐input multi‐output (MIMO) mechanical system characterized by strong aerodynamic cross ...
Mohammad Mahdi Soori +1 more
wiley +1 more source
Predictive value of water swallow test score, serum albumin, and systemic immune-inflammation index for stroke-associated pneumonia in patients with acute isolated pontine infarction. [PDF]
Ding J, Jin H, Ren X, Geng J.
europepmc +1 more source
Advances in research on autophagy in the maintenance of insect–microbe symbiosis
Autophagy plays a dual regulatory role in insect–microbe symbiotic relationships. Beneficial symbiotic bacteria in insects participate in nutrient exchange via the TOR pathway, whereas pathogenic microbes induce immune defense through the AMPK pathway. Autophagy‐related genes regulate development and pathogen clearance during this process.
Yanbin Wang +5 more
wiley +1 more source
Prenatal maternal infection promotes maternal microchimeric cells to alter infection risk in male offspring. [PDF]
Jimena B +10 more
europepmc +1 more source
Tomato yellow leaf curl virus upregulates the Bemisia tabaci UDP‐glycosyltransferase gene UDP‐Bta06664. RNA interference (RNAi) silencing of this gene disrupts phloem feeding—delaying E1 and shortening E2—and reduces both virus acquisition and inoculation, highlighting its potential as an RNAi target.
Zeyu Wan +5 more
wiley +1 more source
Response to "Perhaps Fewer, but Faster: Should we Rethink the 90% Stroke Unit Admission Standard?" [PDF]
Tomek A +6 more
europepmc +1 more source
Uptake, metabolism, and bioremediation of neonicotinoid insecticides in soil–plant systems: A review
This review summarizes the uptake and metabolic transformation of neonicotinoid insecticides in plants, showing that some metabolites exhibit higher toxicity. We also critically assess promising bioremediation strategies using microbes and plant–microbe interactions to reduce residue contamination.
Wenwen Guo +5 more
wiley +1 more source

