Results 141 to 150 of about 554,040 (331)

Therapeutic Effects of Nizubaglustat in a Mouse Model of GM2 Gangliosidosis

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nizubaglustat is a novel selective inhibitor of glucosylceramide synthase (GCS) and the non‐lysosomal glucocerebrosidase (NLGase, GbA2) with brain penetrant properties. It is currently in clinical development as an oral treatment for rare lysosomal storage diseases with neurological involvement. One such disease group called GM2 gangliosidosis,
Kyle Landskroner   +3 more
wiley   +1 more source

Deep Vein Thrombosis in Critically Ill Patients With COVID‐19 Pneumonia

open access: yesJournal of Ultrasound in Medicine, Volume 45, Issue 1, Page 155-170, January 2026.
Objectives The risk of major venous thromboembolism (VTE) among patients with COVID‐19 is high but varies with disease severity. Estimate the incidence of lower extremity deep venous thrombosis (DVT) in critically ill hospitalized patients with COVID‐19, validate the Wells score for DVT diagnosis, and determine patients' prognosis.
Clévio Cezar da Fonseca   +20 more
wiley   +1 more source

Flap Choice in Gender Affirming Phalloplasty Affects Postoperative Complication Rates

open access: yesMicrosurgery, Volume 46, Issue 1, January 2026.
ABSTRACT Background Phalloplasty plays an important role in female‐to‐male (FTM) gender affirmation surgery to create a neophallus that prioritizes aesthetic and functional outcomes. Patients have a variety of flap choices for phalloplasty, but they can often come with complications. This study aimed to evaluate the impact of flap choice on the rate of
Ellen Wang   +9 more
wiley   +1 more source

Intermediate-Term Patency of Saphenous Vein Graft With a Clampless Hand-Sewn Proximal Anastomosis Device After Off-pump Coronary Bypass Grafting [PDF]

open access: bronze, 2009
Tomoki Shimokawa   +5 more
openalex   +1 more source

The role of inflammatory cytokines and hypoxia in varicose vein wall remodelling

open access: yes, 2010
Varicose Veins (VV) affect 10-40% of 30-70 year olds. They have a prominent twisted appearance caused by changes in vein wall thickness. Primary weakening of the vein wall, due to an imbalance in matrix metalloproteinase enzymes (MMP) and their ...
Saunders, Beverley, Saunders, Beverley
core   +1 more source

Upconverting Nanoparticle‐Loaded Microneedles for Near‐Infrared Responsive Delivery of Gonadotropins to Increase Success of In Vitro Fertilization

open access: yesSmall, Volume 22, Issue 1, 2 January 2026.
This paper describes the development of an upconverting particle‐integrated microneedle patch that can release the hormone leuprolide when the patch is exposed to near‐infrared light. This system represents proof‐of‐concept of a painless and automated method of delivering drugs at specific times when repeated time‐sensitive injections are required ...
Vivienne Tam   +8 more
wiley   +1 more source

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