Results 151 to 160 of about 254,830 (314)
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source
Archeomatica, 2015 This work was created to focus the attention on a particular aspect of the equivocation (aliasing) of the measurements made with Differential SAR interferometry (DInSAR) X-band for the presence of snow.
Massimo Morigi
doaj +2 more sources
NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks
Advanced Science, EarlyView.This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang +10 more
wiley +1 more source
Advanced Digital Beamforming Concepts for High Performance Synthetic Aperture Radar (SAR) Imaging
, 2009 This paper reviews advanced multi-channel SAR system concepts for the imaging of wide swaths with high resolution. Several novel system architectures employing both direct radiating arrays and reflector antennas fed by a digitial array are introduced ...
Patyuchenko, Anton +6 more
core
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Advanced Multi-Channel SAR Imaging - Measured Data Demonstration
, 2009 Synthetic Aperture Radar (SAR) is a well-established technique for remote sensing of the Earth. However, conventional SAR systems relying on only a single transmit and receive aperture are not capable of imaging a wide swath with high spatial resolution.
Almeida, Felipe +2 more
core
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
GEOmedia, 2007 TerraSAR-X è sviluppato ed operato dall’Agenzia Spaziale Tedesca (DLR, Deutsches Zentrum für Luft- und Raumfahrt) e da EADS Astrium con l’obiettivo di essere il primo satellite per osservazione della Terra (EO) in grado di fornire globalmente e con ...
Fabrizio Bernardini
doaj
Disorder‐Induced Extremely Low Thermal Conductivity of Graphite Fluoride
Advanced Science, EarlyView.This article investigates the effect of fluorination on the thermal conductivity of graphite fluoride, demonstrating the relationship between structural modification and thermal conductivity in an extreme case. The record‐low through‐plane thermal conductivity measured in exfoliated graphite fluoride flakes was found to correlate with the wide ...
Wonsik Lee +10 more
wiley +1 more source
Advanced Science, EarlyView.A time‐multiplexed nanobody‐functionalized organic electrochemical transistor enables rapid and sensitive detection of three respiratory viral proteins from saliva. Sequentially addressed multi‐gate electrodes on a shared channel achieve around 1 fm detection within 15 min without sample preprocessing. Clinical validation demonstrates high specificity,
Tianrui Chang +13 more
wiley +1 more source