Results 251 to 260 of about 1,026,223 (287)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Advancing SAR Target Recognition Through Hierarchical Self-Supervised Learning with Multi-Task Pretext Training. [PDF]

Sensors (Basel)
Siam MA, Noor DF, Ndoye M, Khan JF.
europepmc   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

SAR Modeling to Predict Ames Mutagenicity Across Different <i>Salmonella typhimurium</i> Strains. [PDF]

Pharmaceuticals (Basel)
Dmitriev AV, Lagunin AA, Rudik AV, Savosina PI, Druzhilovskiy DS, Filimonov DA, Poroikov VV.   +6 more
europepmc   +1 more source

Design of Single‐Atom Catalysts Anchored in N‐Doped Biphenylene Using Symbolic Regression for Electrocatalytic Nitrate Reduction to Ammonia

Advanced Science, EarlyView.
A high‐throughput in silico calculations for NO3RR based on transition metal doped and nitrogen decorated biphenylene network are performed. A symbolic regression is designed to capture the hidden descriptors of NO3RR for hyper dimensional system entailing large geometric variability.
Zheng Shu, Zhangsheng Shi, Huaxian Jia, Huifang Xu, Zian Xu, Zhongheng Li, Man‐Fai Ng, Teck Leong Tan, Fuqiang Huang, Yongqing Cai   +9 more
wiley   +1 more source

Neuroretinal and Photoreceptor Layer Thickness Reduction Associates With Impaired Cardiovascular Health: The UK Biobank Study. [PDF]

Invest Ophthalmol Vis Sci
Peng Y, Zhang Y, Kam KW, Ho M, Sezto S, Au S, Yim CC, Zhang X, Ng MPH, Ip P, Young A, Pang CP, Tham CC, Chen LJ, Yam JC.   +14 more
europepmc   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Integrative bioinformatics analysis for identifying the mitochondrial-related gene associated with immune infiltration in sarcopenia. [PDF]

Medicine (Baltimore)
Yan H, Li Y, Liu Z, Zhou T, Liu K, Xiong L, Huang F.   +6 more
europepmc   +1 more source

Space Borne SAR Traffic Monitoring [PDF]

, 2007
Hartmut Runge, Steffen Suchandt, Alexander Kotenkov, Helko Breit, Martin Vonavka, Ulrich Balss   +5 more
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