Results 261 to 270 of about 1,026,223 (287)

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Engaging Older Adults and Staff in the Co-Design and Evaluation of Socially Assistive Robot and Virtual Reality Activities for Long-Term Care: User-Centered Study. [PDF]

JMIR Aging
Ghosh R, Khan N, Migovich M, Tate JA, Maxwell CA, Newhouse PA, Scharre DW, Tan A, Mion LC, Sarkar N.   +9 more
europepmc   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Bridging mechanism and design: modern medicinal chemistry approaches to thymidylate synthase inhibitors. [PDF]

RSC Adv
Al-Karmalawy AA, Eissa ME, Yousef TA, Al Khatib AO, Hawas SS.   +4 more
europepmc   +1 more source

Organic Electrochemical Transistors in Tissue‐Interfaced Bioelectronics

Advanced Science, EarlyView.
This article reviews the design, fabrication, and biological application of organic electrochemical transistors (OECTs), emphasizing their potential in tissue‐interfaced bioelectronics. It covers the fundamental principles of OECTs, strategies for enhancing tissue interfacing, and the development of skin‐mounted and implantable systems.
Ruixiang Bai, Zeyu Zhao, Feng Yan
wiley   +1 more source

Editorial: Digital health applications of social robots. [PDF]

Front Robot AI
Stanojevic C, Bennett C, Piatt J, Šabanović S.   +3 more
europepmc   +1 more source

A Modular Vaccine Platform Against SARS‐CoV‐2 Based on Self‐Assembled Protein Nanoparticles

Advanced Science, EarlyView.
A modular BP26 nanoparticle vaccine platform incorporating the SpyTag/SpyCatcher system enables high‐density, repetitive antigen display with post‐expression flexibility. Conjugation of the SARS‐CoV‐2 RBD to BP26 nanoparticles elicits strong humoral immunity and confers protection against viral challenge in vivo.
Seojung Lee, Yejin Jang, Yujin Kim, Yumi Shin, Ji‐Joon Song, Meehyein Kim, Sangyong Jon   +6 more
wiley   +1 more source

Chatbot interventions for improving mental health among people in Asia: a systematic review and meta-analysis of randomised controlled trials. [PDF]

BMJ Health Care Inform
Leung WKC, Lam SC, Chan BCL, Chow JNL, Wong YYY, Ng F, Yip CCK, Chan ACK.   +7 more
europepmc   +1 more source