Results 281 to 290 of about 770,289 (341)

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Advanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li   +12 more
wiley   +1 more source

Activity cliff-aware reinforcement learning for de novo drug design. [PDF]

J Cheminform
Hu X, Liu G, Zhao Y, Zhang H.
europepmc   +1 more source

Zinc‐Doping‐Induced Electronic States Modulation of Molybdenum Carbide: Expediting Rate‐Determining Steps of Sulfur Conversion in Lithium‐Sulfur Batteries

Advanced Science, EarlyView.
Zn‐doped molybdenum carbide microflowers (Zn‐Mo2C) are exploited as a sulfur host for Li–S batteries. Zn doping elevates the d‐band center on Mo, enhancing LiPSs anchoring, weakening S─S/Li─S bonds, and reducing Li2S2→Li2S conversion energy barrier from 0.52 to 0.05 eV.
Bin Qin, Yanmei Li, Qun Wang, Si Zhang, Jinglin Zhang, Bin Wang, Peijia Wang, Yuhan Chen, Weiqi Yao, Fang Wang   +9 more
wiley   +1 more source

A Novel Space-Time Coding Echo Separation Scheme with Orthogonal Frequency Division Multiplexing Chirp Waveforms for Multi-Input Multi-Output Synthetic Aperture Radar. [PDF]

Sensors (Basel)
Yao K, Liu C.
europepmc   +1 more source

SARS Revisited

AMA Journal of Ethics, 2006
openaire   +2 more sources

Bioorthogonal Reaction of o‐Quinone with Furan‐2(3H)‐One for Site‐Selective Tyrosine Conjugation and Construction of Bispecific Antibody Complexes

Advanced Science, EarlyView.
A site‐selective, efficient, and mild tyrosine conjugation via tyrosinase oxidation and nucleophilic addition, allowing for site‐selective functionalization of peptides, recombinant proteins, and IgGs. Site‐selective mono‐functionalization of IgGs at Y296 enables the construction of immunoliposomes.
Hongfei Chen, Zhiyi Xu, Yishu Bao, Farshad Shiri, Dingdong Yuan, Yuke Hu, Biquan Li, Bin Zeng, Xiaojing Li, Hao Kong, Zikang Wang, Wilson Chun‐Yu Lau, Zhenyang Lin, Jiang Xia   +13 more
wiley   +1 more source

Apple Detection via Near-Field MIMO-SAR Imaging: A Multi-Scale and Context-Aware Approach. [PDF]

Sensors (Basel)
Shi Y, Ma Y, Geng L.
europepmc   +1 more source

Dual‐Locking the SARS‐CoV‐2 Spike Trimer: An Amphipathic Molecular “Bolt” Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition

Advanced Science, EarlyView.
A new amphipathic molecule, S416 is discovered, that locks the SARS‐CoV‐2 spike protein in its closed state, blocking viral entry. S416 acts as a molecular bolt, binding six sites: three between adjacent RBDs and three connecting NTDs to RBDs. This dual‐locking mechanism stiffens the spike structure and reduces its flexibility.
Shiliang Li, Fang Ye, Yucheng Zheng, Jie Wang, Haoran Peng, Lili Zhu, Lili Chen, Tao Yu, Huan Ge, Jiaqi He, Binghao Zhang, Jiayun Wu, Zhiyi Zhang, Liangliang Jiang, Geng Chen, Ping Zhao, Ke Lan, Zhenjiang Zhao, Xuhong Qian, Ke Xu, Yang Du, Honglin Li   +21 more
wiley   +1 more source

Systemic immune-inflammation index to albumin (SII/ALB) ratio as a novel dual-dimensional powerful predictor for hip fractures in elderly females with diabetes: a postmenopausal longitudinal cohort study. [PDF]

BMC Endocr Disord
Lu J, Wei F, Sun J, Zhai Z, Pan J, Huang S, Wang H, Wang Q, Chu W, Yu J, Huang J, Wu X, Lu W.   +12 more
europepmc   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source