Results 291 to 300 of about 995,592 (330)

Vinyl Acetate‐Enhanced Polyvinyl Chloride Gel with High Electroadhesion and Self‐Heating‐Tunability for Soft Robots in Freezing Environments

open access: yesAdvanced Science, EarlyView.
This study presents a vinyl acetate‐enhanced electroactive polyvinyl chloride gel with low‐voltage deformation, strong electro‐adhesion, and controlled heating. Leveraging these synergistic properties, this work develops soft robots capable of fast locomotion, swarm reconfiguration, and low‐temperature operation (‐50°C).
Chang Wei   +11 more
wiley   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen   +6 more
wiley   +1 more source

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

open access: yesAdvanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu   +12 more
wiley   +1 more source

ChromNet: A Multi‐Task Learning Framework for Cross‐Cell Type Prediction of 3D Chromatin Interactions Using Epigenetic Signals

open access: yesAdvanced Science, EarlyView.
ChromNet enables accurate cross‐cell‐type prediction of chromatin architecture from DNA and epigenetic profiles alone, capturing both conserved and cell‐type‐specific (including disease‐associated) structural features. Its noise‐perturbed multi‐task learning design enhances generalization, enabling precise reconstruction of 3D genome organization even ...
Bin Wang   +5 more
wiley   +1 more source

Three-dimensional reverse CART by rotation-overlap method: CLARP manoeuvre. [PDF]

open access: yesAsiaIntervention
Leung C   +4 more
europepmc   +1 more source

Interpretable PROTAC Degradation Prediction With Structure‐Informed Deep Ternary Attention Framework

open access: yesAdvanced Science, EarlyView.
PROTAC‐STAN, a structure‐informed deep learning framework is presented for interpretable PROTAC degradation prediction. By modeling molecular hierarchies and protein structures, and simulating ternary interactions via a novel attention network, PROTAC‐STAN achieves significant performance gains over baselines.
Zhenglu Chen   +11 more
wiley   +1 more source

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