Results 171 to 180 of about 13,439 (259)

Safety of 3 Tesla Magnetic Resonance Imaging in Active Peripheral Nerve Field Stimulation Device for Facial Pain.

open access: yesStereotact Funct Neurosurg
Chow CT   +18 more
europepmc   +1 more source

Accessibility and Alignment of Trans‐Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein

open access: yesAngewandte Chemie, EarlyView.
Two key binding events that collectively determine the catalytic efficiency of trans‐cleavage: (1) the substrate passing through the gap between the REC and NUC domains, determined by Kpass, and (2) the alignment of the substrate with the catalytic triad of the ribonucleoprotein, determined by Kalign.
Jianyu Hu   +3 more
wiley   +2 more sources

A Subcellular Keap1-Nrf2 Disruption Strategy for Atopic Dermatitis Therapy. [PDF]

open access: yesJ Med Chem
Zhang Z   +7 more
europepmc   +1 more source

Adaptation of a Fluorogenic RNA to N1‐Methylpseudouridine Nucleoside Chemistry

open access: yesAngewandte Chemie, EarlyView.
Several green‐emitting fluorogenic RNA aptamers were evaluated following the replacement of every uridine by N1‐methylpseudouridine (mΨ). Because this modification impaired the function of most aptamers, a directed evolution strategy combining droplet microfluidics, bioinformatics, and rational design was used to identify an aptamer preserving its ...
Patrick P.A. Bertrand   +4 more
wiley   +2 more sources

A DNA G‐Quadruplex‐Targeting Ligand Suppresses c‐MYC Expression: Implications for Gemcitabine‑Resistant Pancreatic Cancer

open access: yesAngewandte Chemie, EarlyView.
PQB‐4, a fluorescent small‐molecule ligand that targets c‐MYC DNA G‐quadruplexes (G4s), showed marked synergy with gemcitabine in resistant PANC‐1 cells (CI = 0.027). In vivo, the ligand reduced tumor weight by 44% in a PANC‐1 xenograft model. These results highlight the therapeutic potential of c‐MYC DNA G4‐targeting ligands for treating gemcitabine ...
Bo‐Xin Zheng   +10 more
wiley   +2 more sources

Robust vision transformer adaptation for UAV imagery. [PDF]

open access: yesFront Artif Intell
Murugesan J   +4 more
europepmc   +1 more source

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