Results 171 to 180 of about 9,215,645 (352)

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Moving Target Signals in High Resolution Wide Swath SAR [PDF]

, 2008
In this paper the impact of two high resolution wide swath synthetic aperture radar imaging techniques, extraction of signals from azimuth subsampled spectra and subpulse azimuth beamsteering on transmit, on ground moving target signals is analyzed ...
Krieger, Gerhard, Gabele, Martina
core  

From Displacement to Angle: Diamond‐Based 3D Rotation Sensing for High‐Precision Cellular Force Measurement

Advanced Science, EarlyView.
Cellular forces are traditionally inferred from displacement measurements, which lack rotational information and are constrained by linear model assumptions. This work replaces displacement with rotational angle for the fundamental mechanical readout.
Linjie Ma, Bicong Wang, Tai Nam Yip, Jiahua Zhang, Yicheng Wang, Luyao Zhang, Yong Hou, Yuan Lin, Zhiqin Chu   +8 more
wiley   +1 more source

Synthetic aperture sonar imaging using compressive sensing and an ultrasound transducer array [PDF]

, 2013
Includes bibliographical references.Compressive sensing (CS) also known as compressive sampling is a technique used to reconstruct or recover the full-length of a signal with only a few non-adaptive measurements.
Jideani, Josiah Chimnanu
core   +1 more source

Digital beamforming and multidimensional waveform encoding for sapceborne radar remote sensing [PDF]

, 2007
This paper introduces the innovative concept of multidimensional waveform encoding for space-borne synthetic aperture radar (SAR). The combination of this technique with digital beamforming on receive enables a new generation of SAR systems with ...
Moreira, Alberto, Gebert, Nicolas, Krieger, Gerhard   +2 more
core  

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Imaging Time Optimization Method for Ship Targets of Bistatic SAR

Leida xuebao
Bistatic Synthetic Aperture Radar (SAR), with the separated transmitter and receiver working in coordination, cannot only achieves high-resolution imaging in the forward-looking mode, but also possesses outstanding concealment and anti-interference ...
Yahui WANG, Qing YANG, Zhongyu LI, Jun’ao LI, Junyan LI, Junjie WU, Jianyu YANG   +6 more
doaj   +1 more source

Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy

Advanced Science, EarlyView.
Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan, Zifan Pei, Jie Wu, Nan Jiang, Qian Li, Yuqi Yang, Jie Cao, Yechen Huang, Shumin Sun, Qialu Du, Zhicheng Liu, Lin Zhang, Fei Gong, Jinhua Zhou, Liang Cheng   +14 more
wiley   +1 more source

Precise Management of n‐Value Distribution at the 2D/3D Interface Enabling Efficient Wide‐Bandgap Perovskite Solar Cells

Advanced Science, EarlyView.
This study elucidates the phase transition pathway of surface‐engineered perovskite films. During spin‐coating, n = 1 2D perovskite dominantly forms, while subsequent annealing drives OA+ release and induces conversion to higher n‐value 2D phases.
Yajie Yang, Jiaxin Ha, Yang Zhang, Yunfan Wang, Ting Jiang, Jingquan Zhang, Lili Wu, Wenwu Wang, Guanggen Zeng, Baoyan Fan, Mohammad Abdul Halim, Xia Hao, Dewei Zhao   +12 more
wiley   +1 more source

High-Fidelity SAR Imaging Under Composite Jamming via Collaborative Sparse Signal Optimization

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
In practical combat scenarios, the high-resolution imaging process of synthetic aperture radar (SAR) is susceptible to diverse forms of electromagnetic jamming, which severely degrades the final imaging quality. To achieve high-fidelity SAR imaging under
Xinrui Li, Baixiao Chen, Jingtian Xu
doaj   +1 more source