Results 241 to 250 of about 61,185 (361)

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

open access: yesAdvanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng   +12 more
wiley   +1 more source

Tyrosinase Driven‐Intracellular Polymerization of a Porphyrin Derivative Induced Immunogenic Death of Melanoma Cells and Strengthened Photodynamic Therapy

open access: yesAdvanced Science, EarlyView.
This study uses tyrosinase, which is highly expressed in melanoma, to drive porphyrins to polymerize and self‐assemble within tumor cells to form retented microstructures. This process induces immunogenic death and activates immune responses (M1 macrophages, dendritic cells, CD8+T cells), turning “cold” tumors into “hot” tumors.
Mian Tang   +9 more
wiley   +1 more source

Sulfur‑Containing Additives for Enhanced Kinetics and Interfacial Stability of Phosphorus Anodes in Li‑Ion Batteries

open access: yesAdvanced Science, EarlyView.
A novel synergistic strategy by employing dual functional sulfur‐containing additives of lithium sulfide (Li2S) and its oxidation product lithium sulfate (Li2SO4) was proposed. Li2SO4 absorbs the solvent molecules to direct the formation of a uniform, Li2O‐rich, and adaptive interphase, which accommodates volume expansion and suppresses parasitic ...
Huixian Xie   +5 more
wiley   +1 more source

Orthogonal Design of Competing Deprotonation Process in Cation‐Mediated Ni(OH)2 for Achieving Industrial Level Biomass Electrooxidation

open access: yesAdvanced Science, EarlyView.
A Cu‐mediated Ni(OH)2 catalyst with orthogonal activity by precise valence engineering simultaneously accelerates rate‐determining aldehyde C─H activation in HMF oxidation and impedes O─H deprotonation in competing OER. This multi‐functional synergistic catalysis enables FDCA production at industrial‐level current densities without sacrificing FEFDCA ...
Junge Yang   +7 more
wiley   +1 more source

Through-the-wall SAR Imaging Based on Chaotic FM Signal

open access: hybrid, 2011
Qin-yan Tan, Leung Henry, Yaoliang Song
openalex   +1 more source

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