Results 201 to 210 of about 18,526,084 (268)

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Symptom‐Driven Prediction of Chronic Multimorbidity with a Macro–Micro Heterogeneous Graph Neural Network

Advanced Science, EarlyView.
Clinical symptoms offer a window into multimorbidity. A macro‐micro heterogeneous graph neural network integrates clinical records with biomedical knowledge to improve patient‐level symptom‐disease association learning and visit‐level multimorbidity completion.
Yiheng Ye, Miaoru Han, Siqiao Tang, Zongxiang Zhang, Haichen Shen, Bingzhen Sun, Yan Zhang, Xiaodong Chu, Lijuan Deng, Chaoyang Zheng, Qingchun Huang, Kun Bao, Ronghua Zhang, Yong Wang, Fengwei Zhang, Xiaoli Chu   +15 more
wiley   +1 more source

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Gapless Complete Genome and Multi‐Omics Illuminate Immune Adaptation and Host‐Virus Interactions in a Coronavirus Reservoir

Advanced Science, EarlyView.
We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang, Sheng Zhang, Linxia Ouyang, Xin Du, Xin Huang, Zhilin Wang, Huixian Xie, Jiale Tang, Liyi Lou, Wenqing Ling, Weihao Wang, Jiang Zhou, Zhen Liu, Yibo Hu, Fuwen Wei, Guangping Huang   +15 more
wiley   +1 more source

XChrom: A Cross‐Cell Chromatin Accessibility Prediction Model Integrating Genomic Sequence and Cellular Context

Advanced Science, EarlyView.
XChrom is a deep learning framework that integrates genomic sequence and single‐cell context to predict chromatin accessibility. It generalizes to unseen cells and genomic regions, enabling cross‐sample and cross‐species analysis. Applied to COVID‐19 patient data, XChrom reveals key transcriptional regulatory mechanisms and disease‐associated ...
Yuanyuan Miao, Xuan Liang, Wenwen Zhang, Dongmei Han, Yurun Li, Zhen Wang   +5 more
wiley   +1 more source

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER‐phagy and Suppress Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Wenxiu Ru, Lunbiao Gan, Yu Lu, Yujing Guo, Qian Huang, Sha Yin, Fengze Nie, Sijia Di, Jiaqi Ning, Siyu Yao, Huanhuan Wan, Le Liu, Zehua Liu, Fa Yang, Weijun Qin, Weihong Wen   +15 more
wiley   +1 more source

Gel‐Free Capture of Microvolt‐Level Neural Signatures Via a 3D Monolithic Carbon Fiber Dry Electrode

Advanced Science, EarlyView.
A compressible carbon fiber/PEDOT:PSS electrode enables gel‐free contact at hairy scalp sites. Its conductive porous framework supports low interfacial impedance and retains contact performance after repeated mechanical and sweat‐related challenges.
Haoxuan Sun, Nikolay Novitskiy, Dongwook Jang, Yixiang Liu, Shaoqi Pan, Ting Huang, Yitong Li, Huisi Yang, Leonardo Nicholas Adi Wijaya, Md Masruck Alam, Patrick CM Wong, Zhaoli Gao   +11 more
wiley   +1 more source

Special Issue Editorial: Advanced Science for Tissue‐Interfaced Organic Bioelectronics

Advanced Science, EarlyView.
Tae‐il Kim, Shiming Zhang, Simone Fabiano   +2 more
wiley   +1 more source

Some of the next articles are maybe not open access.

Related searches:

System status and calibration of the F-SAR airborne SAR instrument

2011 IEEE International Geoscience and Remote Sensing Symposium, 2011
The F-SAR airborne SAR instrument represents the successor of the E-SAR system of the German Aerospace Center (DLR), which has been extensively used in the last three decades. Its development was triggered by the current demand for data being simultaneously acquired at different wavelengths and polarisations as well as by the demand for very high ...
Andreas Reigber, Marc Jäger 0001, Jens Fischer, Ralf Horn, Rolf Scheiber, Pau Prats, Anton Nottensteiner   +6 more
openaire   +4 more sources

Construction and application of tomographic SAR system based on GB-SAR system

2014 IEEE Geoscience and Remote Sensing Symposium, 2014
Synthetic Aperture Radar (SAR) provides high-resolution images regardless of weather conditions and solar illumination. However, a SAR image projects the 3D distributed targets onto a 2D plane in range and azimuth. Tomographic SAR (TomoSAR) is a technique to generate 3D image by adding the vertical baselines to the conventional SAR image acquisition ...
Younghun Ji, Hyangsun Han, Hoonyol Lee
openaire   +1 more source