Results 51 to 60 of about 7,518 (208)

Triosephosphate isomerase from Fasciola hepatica: high‐resolution crystal structure as a drug target

Acta Crystallographica Section F, Volume 81, Issue 9, Page 381-387, September 2025.
The high‐resolution crystal structure of triosephosphate isomerase from F. hepatica was solved at 1.51 Å resolution in its monoclinic form, revealing details of the dimer interface critical for enzyme function. Molecular docking with the fasciolocide triclabendazole suggests selective binding near nonconserved residues, highlighting this enzyme as a ...
Georgios Kontellas, David J. Studholme, Mark van der Giezen, David J. Timson, Jennifer A. Littlechild, Michail N. Isupov   +5 more
wiley   +1 more source

A representação da mulher em Ensaio sobre a cegueira de José Saramago [PDF]

, 2022
Durante séculos o papel das mulheres na sociedade patriarcal foi o de mãe e esposa ou, em contrapartida, o de prostituta. A literatura serviu-se destes estereótipos para representá-las como mulheres inocentes o femmes fatales, sem ter em conta as nuances
Hovsepyan Vardanyan, Vardush
core   +1 more source

DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis

Brain and Behavior, Volume 15, Issue 8, August 2025.
H2 downregulates DGKζ and CCTα to alleviate brain damage in septic mice. The change in DGKζ has been shown to balance the transformation between DAG and PA, and it may also interact with PTEN. ABSTRACT Objectives: Therapeutic effects of hydrogen (H2) on sepsis‐associated encephalopathy (SAE), a severe neuroinflammatory disease, have been reported, but ...
Yuanyuan Bai, Zeyu Li, Donglai Yan, Yi Jiang, Beibei Dong, Yonghao Yu   +5 more
wiley   +1 more source

Quando se morre duas vezes: Lázaro por Hilda, J. Queiroz e Saramago [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em LiteraturaO milagre da ressurreição de Lázaro ocorreu há quase 2.000 anos, segundo a Bíblia, o livro mais lido no ocidente ...
Mafra, Suzana
core  

José Saramago’s theatre as seen by himself

Revista de Filología Románica, 2012
We transcribe, in this article, the words pronounced by the Portuguese author José Saramago, who was awarded in 1998 the Nobel Prize for Literature, in occasion of a lecture given at the Complutense University of Madrid in may 1995.
Mª Josefa Postigo
doaj   +1 more source

Saramago, Agamben, and the ‘Invention of an Epidemic’

, 2023
Saramago and Agamben confronted a pandemic in very different ways: the former as literary fiction, the latter as a real instrument of political oppression. However, both used it to shed light on the critical dilemmas of the sovereign state and its democratic form.
openaire   +2 more sources

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS‐CoV‐2 endoribonuclease Nsp15

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Spyros D. Chatziefthymiou, Maria Kuzikov, Sara Afandi, Greta Kovacs, Sukrit Srivastava, Andrea Zaliani, Andrey Gruzinov, Guillaume Pompidor, Michele Lunelli, Golam Rizvee Ahmed, Jörg Labahn, Johanna Hakanpää, Björn Windshügel, Michael Kolbe   +13 more
wiley   +1 more source

"Terra do pecado": El «factor Dios» en el primer Saramago

Actio Nova, 2019
El pensamiento y las declaraciones públicas de Saramago sobre la cuestión religiosa no desencadenarían tantas reacciones (a favor o en contra) si el autor no hubiese escrito obras mayores como O Evangelho Segundo Jesus Cristo e Caim.
Carlos Nogueira
doaj   +1 more source

Ecological Crises and Ecopolitics Research in Australia

Australian Journal of Politics &History, Volume 71, Issue 1, Page 147-165, March 2025.
It is difficult to exaggerate the scale of contemporary ecological crises. These challenges, particularly climate change, necessitate new modes of politics and policy, even potentially new institutions, that seem anathema to the emphases of traditional accounts of environmental political science.
Matt McDonald, Susan Park, Kirsty Anantharajah, Anthony Burke, Danielle Celermajer, Megan C. Evans, Robyn Eckersley, Robyn Gulliver, Rebecca McNaught, Wesley Morgan, Melodie Ruwet, Jonathan Symons, David Schlosberg, Anselm Vogler   +13 more
wiley   +1 more source

Desconcerto do mundo: Que farei com este livro? de José Saramago - contrariedades, dissonâncias e utopia [PDF]

, 2022
Publicada pela primeira vez em 1980 pela Editorial Caminho, a peça de teatro Que farei com este livro? de José Saramago é republicada, em 2015, pela Porto Editora e reimpressa em 2019.
Martins Coelho, Leonor
core   +1 more source