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The interplay between M2-like macrophages and Th17.1 cells promotes the progression of early-stage sarcoidosis [PDF]
Cell Communication and SignalingBackground Sarcoidosis is pathologically characterized by non-necrotizing granulomas inflammation. Despite the high spontaneous remission rate, a remarkable number of sarcoidosis patients undergo persistent progression.
Yu Zhao +16 more
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Ophthalmology, 2015 Sarcoidosis is a disease characterized by noncaseating granulomatous infiltration of 1 or more organs. In North America, after the lungs and thoracic lymph nodes, the skin is the next most commonly involved organ. Data from multiple studies indicate a coaction between genetic and environmental factors in immunologically susceptible hosts. The disease's
Christopher K H, Burris +2 more
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Clinics in Dermatology, 2007 AbstractSarcoidosis is a multisystemic disorder of unknown cause characterized by the formation of immune granulomas in involved organs. It is an ubiquitous disease with incidence (varying according to age, sex, race and geographic origin) estimated at around 16.5/100,000 in men and 19/100,000 in women.
Valeyre Dominique +3 more
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The Lancet, 1960 The historical background to the disorder is unfolded. It was originally regarded as a dermatological curiosity, and later sarcoidosis was recognized as a disorder diffusely involving most tissues of the body. Clinical syndromes described include those presenting to the dermatologist, ophthalmologist, chest physician and radiologist, gastroenterologist
M M, CUMMINGS, M, MICHAEL
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Immune mechanisms in fibrotic pulmonary sarcoidosis
European Respiratory Review, 2022 Sarcoidosis is an immune-mediated disorder. Its immunopathology has been steadily mapped out over the past few decades. Despite this, the underpinning mechanisms for progressive fibrotic sarcoidosis is an almost uncharted area.
Praveen Weeratunga +2 more
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Health-Related Quality of Life (HRQoL) in Sarcoidosis: Diagnosis, Management, and Health Outcomes
Diagnostics, 2021 Health-related quality of life (HRQoL), though rarely considered as a primary endpoint in clinical trials, may be the single outcome reflective of patient priorities when living with a health condition.
Lesley Ann Saketkoo +21 more
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Scientific Reports, 2021 Sarcoidosis is granulomatous disease, which complex etiology is yet to be fully discovered. In the majority of cases its course is self-limiting. However it can have different clinical manifestations and can be debilitating condition with great impact on
Łukasz Gwadera +6 more
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Cutis, 2022 A Pink, elevated, granulomatous, indurated plaques on the face, including the nasal alae, of a 52-year-old woman with a darker skin tone. B Orange and pink, elevated, granulomatous, indurated plaques on the face of a 55-year-old woman with a lighter skin tone.
Candrice R, Heath, Richard P, Usatine
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Life, 2023 Cardiac sarcoidosis (CS) is a rare inflammatory disorder characterised by the presence of non-caseating granulomas within the myocardium. Contemporary studies have revealed that 25–30% of patients with systemic sarcoidosis have cardiac involvement, with ...
Joseph Okafor +3 more
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Nature Reviews Disease Primers, 2019 Sarcoidosis is an inflammatory disorder of unknown cause that is characterized by granuloma formation in affected organs, most often in the lungs. Patients frequently suffer from cough, shortness of breath, chest pain and pronounced fatigue and are at risk of developing lung fibrosis or irreversible damage to other organs.
Grunewald, Johan +5 more
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