Results 101 to 110 of about 213,070 (226)

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

OX40/OX40L modulation: A target for regulating T cells in cutaneous inflammatory disorders

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 8, Page 1318-1331, August 2026.
OX40 and OX40L are a co‐stimulatory immune checkpoint pair. Modulation of this pair impacts multiple immune phenotypes and is an attractive target for immunotherapy in dermatological disorders. Trials are underway with the majority in atopic dermatitis and currently in phase 3 trials.
Aditya K. Gupta, Julia Steriopoulos, Vasiliki Economopoulos, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Life Course Malaria Exposure and SARS‐CoV‐2 Seroepidemiology in Ugandan Adolescents: A Longitudinal Study Nested in a Birth Cohort

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1012-1027, August 2026.
ABSTRACT Background COVID‐19 has had major global health impacts, yet reported morbidity and mortality have been lower in Africa despite serological evidence of widespread infection. Malaria has been proposed as a potential modifier of susceptibility to and outcomes of SARS‐CoV‐2 infection.
Ludoviko Zirimenya, Doreen Nayebare, Claire Baine, Jacent Nassuuna, Milly Namutebi, Christopher Zziwa, Denis Nsubuga, Fred Kiwudhu, Florence Akello, Josephine Tumusiime, Gloria Oduru, Grace Kabami, Hellen Akurut, Rachel Nakyesige, Agnes Natukunda, Anne Wajja, Lawrence Lubyayi, Simon Kimuda, Gyaviira Nkurunungi, Jennifer Serwanga, Katie J. Doores, Emily L. Webb, Alison M. Elliott   +22 more
wiley   +1 more source

Sarcoma de Kaposi

Revista de Ciencias Médicas de Pinar del Río, 2016
El sarcoma de Kaposi ó reticuloendoteliosis angiógena, como también se conoce a esta entidad dermatológica, fue descrito por primera vez por Moritz Kaposi  en 1872 y por un siglo fue una enfermedad rara de varones ancianos.
Liusy Caridad Arías Benitez, Aracelys Alonso Álvarez, Katia Molina Aldas, Joel Jiménez Valladares   +3 more
doaj  

Sarcoma de Kaposi em paciente transplantada renal em uso de Fk-506 Kaposi's Sarcoma in a renal transplant patient receiving Fk-506

Anais Brasileiros de Dermatologia, 2002
O Sarcoma de Kaposi (SK) é neoplasia maligna multicêntrica, cutânea e extracutânea, que tem sido descrita em pacientes transplantados renais que recebem terapia imunossupressora clássica.
Jorge David Rocha Zanol, André Vicente Esteves de Carvalho, Sérgio Martinez Lecompte, Elisa Gobbato Trez   +3 more
doaj   +1 more source

Kaposi Sarcoma Presenting as Retroperitoneal Lymphadenopathy: A Case Report

Case Reports in Oncology
Introduction: Kaposi sarcoma is a mesenchymal vascular tumor caused by human gammaherpesvirus 8. Kaposi sarcoma is typically associated with immunocompromise and HIV, and has a classical form seen in elderly men of Mediterranean or Eastern ...
Karam Elsolh, Kevin Zbuk, Haroon Yousuf
doaj   +1 more source

Imaging of Kaposi sarcoma in a transplanted liver: A rare case report

The Egyptian Journal of Radiology and Nuclear Medicine, 2015
In post-transplant patients, de novo malignancies such as post-transplant lymphoproliferative disease (PTLD), lung carcinoma, renal cell carcinoma, cutaneous malignancies, and Kaposi sarcoma are now seen.
Saumya Gupta, Samarjit S. Ghuman, T.B.S. Buxi, Hariprasad Sudarsan, Sankalp Sethi, Ajit K. Yadav, Anurag Yadav, Kishan S. Rawat, Naimish Mehta, Seema Rao   +9 more
doaj   +1 more source

Genital Kaposi sarcoma in a HIV and syphilis co-infected patient: case presentation

BMC Infectious Diseases, 2019
Background Kaposi sarcoma, as an epidemiological factor, is associated with acquired immunodeficiency syndrome (AIDS) and it is related to human herpes virus (HHV-8), as well as a higher prevalence in males and non-genital involvement.
Helena Lucia Barroso dos Reis, Dennis de Carvalho Ferreira, Neide Aparecida Tosato Boldrini, Carolina Galvão, João Victor Jacomele Caldas, Marize Freitas Santos Neves, Philippe Godefroy   +6 more
doaj   +1 more source

Mortalidade por Sarcoma de Kaposi no Brasil e Regiões entre 1996 e 2023: Análise de Tendência Temporal

Revista Brasileira de Cancerologia
Introdução: O sarcoma de Kaposi é uma neoplasia vascular multicêntrica, clinicamente associada à síndrome da imunodeficiência adquirida (Aids), que pode acarretar o óbito. Objetivo: Verificar a tendência temporal da mortalidade por sarcoma de Kaposi nas
Érika Costa Lopes, Rafaella Nascimento da Silva Brito, Eriksen Alexandre Costa Gonçalves, Saul Rassy Carneiro   +3 more
doaj   +1 more source

Isolated Kaposi Sarcoma of the Tonsil: A Case Report and Review of the Scientific Literature

Case Reports in Otolaryngology, 2015
Kaposi sarcoma is a tumour caused by human herpes virus 8, also known as Kaposi sarcoma-associated herpes virus. It usually affects the skin and oral mucosa; however, it can also sometimes affect the lungs, the liver, the stomach, the bowel, and lymph ...
Barbara Pittore, Carlo Loris Pelagatti, Francesco Deiana, Francesco Ortu, Elena Maricosu, Sergio Cossu, Giovanni Sotgiu   +6 more
doaj   +1 more source