Results 161 to 170 of about 391,439 (237)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Data-Driven Defragmentation: Achieving Value-Based Sarcoma and Rare Cancer Care Through Integrated Care Pathway Mapping. [PDF]

J Pers Med
Fuchs B, Heesen P.
europepmc   +1 more source

Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells [PDF]

, 2017
Barrott, Jared J, Capecchi, Mario R, Grossmann, Allie, Haldar, Malay, Hedberg, Matthew L, Illum, Benjamin E, Jin, Huifeng, Jones, Kevin B, Wang, Yanliang   +8 more
core   +2 more sources

Development and validation of a novel model for patients with soft tissue sarcoma who received neoadjuvant chemotherapy. [PDF]

Sci Rep
Jian C, Huang D, Huang Y, Chen X, Zheng Z.   +4 more
europepmc   +1 more source

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

Primary synovial sarcoma of kidney- a diagnostic and interventional enigma. [PDF]

Urol Case Rep
Sairam CL, Balabhaskar H, Kumar GM, Haris CH, Harikrishnan AB, Jayadevan J.   +5 more
europepmc   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Ewing sarcoma of the hand: A rare case report with diagnostic and management considerations. [PDF]

Int J Surg Case Rep
Ali SS, Khurram MF, Singh N, Anand S.
europepmc   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, EarlyView.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

From Intensification to Optimization: Balancing Efficacy, Safety, and Costs in High-Risk Localized Soft Tissue Sarcomas. [PDF]

Cancers (Basel)
Fuchs B, Schelling G, Glanzmann C, Studer G, On Behalf Of The Swiss Sarcoma Network.   +4 more
europepmc   +1 more source