Results 161 to 170 of about 734,103 (389)

Multimodality management of soft tissue sarcomas [PDF]

, 1990
Soft tissue sarcomas are a heterogeneous group of malignant tumours arising from connective tissues of mesenchymal origin. By definition sarcomas arising from bone or cartilage are excluded though they have much in common in their behaviour as well as in
Brincat, Stephen
core  

Mathematical Modeling of the HIV/Kaposi’s Sarcoma Coinfection Dynamics in Areas of High HIV Prevalence [PDF]

, 2013
Edward M. Lungu, Tyler Massaro, E. J. Ndelwa, Neterindwa Ainea, Symon Bilesi Chibaya, N. J. Malunguza   +5 more
openalex   +1 more source

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

Advanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao, Matthew F. Yee, Chaitanya N. Parikh, Boyang Ma, Yueying Cao, Yu‐Huan Shih, Joae Qiong Wu, Marcus Ruscetti, Shun‐Qing Liang, Wen Xue   +9 more
wiley   +1 more source

Role, Timing and Technique of Radiotherapy in Pediatric Pleuropulmonary Synovial Sarcoma [PDF]

, 2016
Corrado Spatola, Alessandra Tocco, Roberto Milazzotto, Antonio Pagana, Ilenia Chillura, Roberta Bevilacqua, Carmelo Militello, Vincenzo Salamone, L. Raffaele, Marcello Migliore, Giuseppe Privitera   +10 more
openalex   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Targeting the EphA2 pathway: could it be the way for bone sarcomas?

Cell Communication and Signaling
Bone sarcomas are malignant tumors of mesenchymal origin. Complete surgical resection is the cornerstone of multidisciplinary treatment. However, advanced, unresectable forms remain incurable.
Giorgia Giordano, Cristina Tucciarello, Alessandra Merlini, Santina Cutrupi, Ymera Pignochino   +4 more
doaj   +1 more source

The role of free flap reconstruction after resection of extremity and trunk soft tissue sarcomas. Results of two referral centers in Argentina

Clinical Surgical Oncology
Introduction: For patients affected by extremity or trunk soft-tissue sarcomas (STS) large resections might be needed to achieve negative margins. This is a common scenario especially in locally advanced or recurrent tumors often within a pre-irradiated ...
Sergio D. Quildrian, Walter S. Nardi, María G. Vega, Jorge A. Chapela   +3 more
doaj   +1 more source

Myeloid sarcoma is associated with superior event‐free survival and overall survival compared with acute myeloid leukemia

, 2008
Apostolia M. Tsimberidou, Hagop M. Kantarjian, Sijin Wen, Michael J. Keating, Susan O’Brien, Mark Brandt, Sherry Pierce, Emil J. Freireich, L. Jeffrey Medeiros, Elihu H. Estey   +9 more
openalex   +1 more source

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.

New England Journal of Medicine, 1995
E. Cesarman, Yuan Chang, P. Moore, J. Said, D. Knowles   +4 more
semanticscholar   +1 more source

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, EarlyView.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source