Results 71 to 80 of about 53,706 (285)

Discovery of a Baloxavir‐Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo

Advanced Science, EarlyView.
Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu, Kai Tang, Jiahui Zhou, Gabriel Pino‐Peco, Nerea López‐Carrobles, Raquel Bello‐Morales, Daniel Galdo‐Torres, Lina Zhang, Federico Gago, José Antonio López‐Guerrero, Xinyong Liu, Peng Zhan, Luis Menéndez‐Arias   +12 more
wiley   +1 more source

Kaposi's Sarcoma: clinical and pathological aspects in patients seen at the Hospital Universitário Cassiano Antônio Moraes - Vitória - Espírito Santo - Brazil Sarcoma de Kaposi: achados clínico-patológicos nos pacientes atendidos no Hospital Universitário Cassiano Antônio Moraes - Vitória - Espírito Santo - Brazil

Anais Brasileiros de Dermatologia, 2012
BACKGROUND: Kaposi's sarcoma is a neoplasm of endothelial origin that is divided into four distinct types according to the clinical characteristics and the affected population: Classic (in elder men of Jewish or Mediterranean origin); Epidemic (in ...
Ricardo Montibeler Tiussi, Antonio Luiz de Oliveira Caus, Lucia Martins Diniz, Elton Almeida Lucas   +3 more
doaj   +1 more source

Sarcoma de Kaposi en Infección por VIH captado en atención primaria, a propósito de un caso

Mediciencias UTA, 2022
Introducción: El virus de la inmunodeficiencia humana pertenece a la familia de lentivirus, cuya infección da como resultado la destrucción del sistema inmunológico.
Paola Alejandra Silva Gutiérrez, Ariel Mena Amaluiza, Salomé Argotti Zumbana   +2 more
semanticscholar   +1 more source

The Evolution and Recent Advances in Diagnostic Criteria for Idiopathic Multicentric Castleman Disease

American Journal of Hematology, EarlyView.
Idiopathic Multicentric Castleman Disease. ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare cytokine‐driven disorder characterized by systemic inflammation, organ dysfunction, and altered lymph node microscopic architecture. Over the past decade, diagnostic criteria have evolved significantly, integrating clinical, histopathological,
FNU Alnoor, Nicholas C. Spies, Jyoti Kumar, Peyman Samghabadi, Oscar Silva, Matt X. Luo, Karen M. Chisholm, Jingjing Zhang, Alexandra Rangel, David Ng, Peng Li, Robert S. Ohgami   +11 more
wiley   +1 more source

Remembering the forgotten child: the role of immune checkpoint inhibition in patients with human immunod eficiency virus and cancer. [PDF]

, 2019
Patients with human immunodeficiency virus (HIV) infection have a high risk of developing virally-mediated cancers. These tumors have several features that could make them vulnerable to immune checkpoint inhibitors (ICIs) including, but not limited to ...
Adashek, Jacob J, Galanina, Natalie, Junior, Pedro Nazareth Aguiar, Kurzrock, Razelle   +3 more
core  

HIV-assoziierte Malignome [PDF]

, 1999
Kaposi's sarcoma (KS), Non-Hodgkin's lymphma (NHL) and invasive cervical cancer are considered AIDS-defining malignancies. The incidence of Kaposi's sarcoma has recently been increased as a secondary manifestation of AIDS.
Hartenstein, R., Hentrich, Marcus, Jäger, H.   +2 more
core   +1 more source

Identification of ferroptosis‐related genes involved in chronic obstructive pulmonary disease based on bioinformatics analysis

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Green part represents the bioinformatics analysis approach. Yellow part represents the ideas of animal experiment. Abstract Background Chronic obstructive pulmonary disease (COPD) is a type of chronic respiratory disease.
Xuejing Luan, Jinghui Xie, Lu Zhang, Xiao Ma, Lichangtian Jiao, Jie Zhu   +5 more
wiley   +1 more source

Sarcoma de Kaposi ocular. Presentación de un caso.

Gaceta Médica Espirituana, 2012
Fundamento: el sarcoma de Kaposi es una enfermedad tumoral descrita por primera vez por el médico húngaro Morita Kaposi en 1872 y puede presentarse con marcada frecuencia en pacientes seropositivos como enfermedad marcadora de sida. Presentación de caso:
Axel López Valdés, Vivian María Couce Herrera, Erians Valdés Pérez, Roxana María Almanza Alarcón, Edelby Escobar Carmona   +4 more
doaj  

SARCOMA DE KAPOSI EM PACIENTE COM HIV/AIDS: REVISÃO DE LITERATURA

Revista Saúde - UNG-Ser, 2022
Introdução: A Síndrome da Imunodeficiência Adquirida (AIDS sigla em inglês para – Acquired Immunodeficiency Syndrome) é a manifestação clínica avançada decorrente de um quadro de imunodeficiência causado pelo vírus da Imunodeficiência Humana (HIV – Human
Vinicius Lodi Cordeiro Karabolsak, Jhonnathan Márcio Ribeiro da Silva, Andréa Regiani Alves   +2 more
semanticscholar   +1 more source

Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore Their Impact on FGFR1 Signaling

ChemBioChem, Accepted Article.
Fibroblast growth factor 2 (FGF2) regulates signal transduction by forming complexes with its receptors, FGF receptors (FGFRs), and heparan sulfate (HS), playing a crucial role in biological systems. Although HS has been suggested to modulate FGF/FGFR signaling as a co‐receptor, multiple hypotheses exist regarding how HS affects FGF/FGFR signaling, and
Yuga Okada, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando   +5 more
wiley   +1 more source