Results 71 to 80 of about 16,553 (172)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, Volume 19, Issue 5, Page 1471-1492, May 2025.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He, Kai Yuan, Junming Pan, Shaoping Weng, Chaozheng Li, Yihong Chen, Jianguo He   +6 more
wiley   +1 more source

Sarcoma de Kaposi da laringe - Caso clínico

, 2011
Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, v. 49 n.
Sofia Caetano, Natércia Silvestre, António Paiva, Clara Silva, Jorge Miguéis, Carla Gapo, Maria José Julião, Ana Margarida Amorim, Isabel Ramos   +8 more
openaire   +3 more sources

Prevalence of Kaposi’s sarcoma-associated herpesvirus in Uygur and Han populations from the Urumqi and Kashgar regions of Xinjiang, China [PDF]

, 2017
Kaposi’s sarcoma-associated herpesvirus (KSHV) is the infectious etiologic agent associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman disease.
Cui, Meng, Han, Li-Li, Liu, Zhen-Qiu, Shu, Zhan-Jun, Wood, Charles, Yang, Yang, Zeng, Yan, Zhang, Tiejun, Zheng, Jun   +8 more
core   +1 more source

Prostaglandins and Skin Cancer: An Old Pathway With New Insights in Cutaneous Oncology

International Journal of Dermatology, EarlyView.
Krisztian Nemeth
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Tumor in an Adult Male Located in the Lower Extremity: A Case Report

Clinical Case Reports, Volume 13, Issue 5, May 2025.
ABSTRACT Masson's tumor is a rare condition that can mimic malignancy, particularly when located in atypical regions. This case emphasizes the importance of considering this diagnosis in unusual anatomical locations and highlights the critical role of histopathological evaluation in achieving an accurate diagnosis.
Mariana Al Hawa, Serena Saade, William Abou Shahla, Dana Saadeh   +3 more
wiley   +1 more source

Recurrent Malignant Melanoma on the Tongue: A Case Report and Review of the Literature

Cancer Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background Melanoma of the oral mucosa is an uncommon cancer arising from the tissues lining the mouth. Among oronasal malignant melanomas, tongue melanoma makes up a mere 2%. Optimal treatments for this rare and often late‐stage disease remain elusive.
Maziar Motiee‐Langroudi, Athena Farahzadi, Pouyan Aminshakib   +2 more
wiley   +1 more source

Sarcoma de Kaposi faríngeo: presentación de un caso

Universitas Médica, 2014
El artículo reseña un caso clínico de un hombre de 52 años de edad, con infección por HIV, quien presenta la aparición de una masa exofítica en el paladar blando y la base de la lengua. Esta lo llevó a un cuadro de disfagia y dificultad respiratoria progresiva, manejada de urgencias con traqueostomía y gastrostomía. El servicio de patología reportó una
Juana Angel, Daniel Fernando Izquierdo Gracia   +1 more
openaire   +4 more sources

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, Volume 9, Issue 5, May 2025.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source