Results 101 to 110 of about 129,284 (273)

Bidirectional transitions of sarcopenia states in older adults: The longitudinal evidence from CHARLS

Journal of Cachexia, Sarcopenia and Muscle
Background Sarcopenia, the age‐related loss of muscle mass and function, brings multiple adverse outcomes including disability and death. Several sarcopenia consensuses have newly introduced the premorbid concept of possible sarcopenia and recommended ...
Ya‐Xi Luo, Xiao‐Han Zhou, Tian Heng, Ling‐Ling Yang, Ying‐Hai Zhu, Peng Hu, Xiu‐Qing Yao   +6 more
doaj   +1 more source

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Age-related deficits in skeletal muscle recovery following disuse are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. [PDF]

, 2016
Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and ...
Baar, Keith, Baehr, Leslie M, Bodine, Sue C, De Sousa, Luis Gustavo, Marcotte, George, Marshall, Andrea G, West, Daniel WD   +6 more
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

The Aging Neuromuscular System and Motor Performance [PDF]

, 2016
Age-related changes in the basic functional unit of the neuromuscular system, the motor unit, and its neural inputs have a profound effect on motor function, especially among the expanding number of old (older than ∼60 yr) and very old (older than ∼80 yr)
Hunter, Sandra K., Keenan, Kevin, Pereira, Hugo M.   +2 more
core   +2 more sources

Association of Skeletal Muscle, Body Fat and Frailty With Prolonged Length of Hospital Stay Following Colectomy for Adenocarcinoma: A Pilot Case‐Control Study

Health Care Science, EarlyView.
ABSTRACT Physical fitness is well‐known to be associated with health outcomes. This pilot study examined the impact of different measures of fitness on length of stay following colectomy. A case‐control study was designed to evaluate the effect of skeletal muscle mass, body fat, and frailty measures on post‐operative length of stay (LOS).
Annmarie Butare, Justin Drake, Michael D. Honaker   +2 more
wiley   +1 more source

Nonlinear association of triglyceride‐glucose body mass index with all‐cause mortality in postmenopausal women, a retrospective cohort study: Evidence from the 2001 to 2014 National Health and nutrition examination survey

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background The triglyceride‐glucose body mass index (TyG‐BMI) is a novel indicator combining an insulin resistance proxy (TyG index) with adiposity. It remains unclear how TyG‐BMI relates to long‐term mortality risk in postmenopausal women, a group prone to metabolic changes after menopause.
Xiliang Wang, Kaiyue Wang, Chang Tan, Yuexin Yu   +3 more
wiley   +1 more source

Association of Characteristics between Acute Stroke Patients and Sarcopenia: A Cross-Sectional Study [PDF]

운동과학
PURPOSE This study aimed to identify the prevalence of sarcopenia among acute stroke patients, differences in characteristics based on the presence of sarcopenia, the association between functional and sarcopenia factors, and the association between ...
So-Yeong Kim, Byeong-Geun Kim, Se-Ju Park   +2 more
doaj   +1 more source

Comment on: "Longitudinal Associations Between Baseline Sarcopenia and Knee Osteoarthritis Progression and Risk of Knee Replacement" ‐ Intramuscular Fat Infiltration: A Hidden Covariate in the Sarcopenia–Knee Osteoarthritis Association? Leveraging OAI MRI Data for Adjustment

Arthritis &Rheumatology, Accepted Article.
Huihui Wu, Zhi Wang, Liang Guo
wiley   +1 more source

Chondroitin sulfate restores muscle mass via gut–muscle axis remodeling through sugar–bile acid metabolism reprogramming

iMeta, EarlyView.
The graphical abstract illustrates the molecular mechanism by which chondroitin sulfate (DCS) alleviates glucocorticoid‐induced myopathy through the gut–muscle axis. DCS selectively enriches L. johnsonii Z‐RW, enhancing bshA‐encoded BSH activity to promote bile acid deconjugation and reduce the sugar–bile acid ratio, thereby re‐establishing intestinal ...
Ruiyun Wu, Tao Wen, Nan Shang, Penghao Xie, Zhenyu Wang, Hang Li, Shaobo Li, Dequan Zhang   +7 more
wiley   +1 more source