Results 161 to 170 of about 1,242,031 (332)

The NSP5, ORF6 and NSP13 of SARS‐CoV‐2 Cooperate to Modulate Inflammatory Cell Death Activation

Advanced Science, EarlyView.
ZBP1 is capable of initiating a large cell death complex to induce programmed cell death during SARS‐CoV‐2 infection. However, SARS‐CoV‐2 can inhibit the activation of ZBP1‐mediated cell death by targeting key components of this complex. This suppression of ZBP1‐mediated cell death may account for the increased mortality observed in patients co ...
Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng   +16 more
wiley   +1 more source

Quantifying absolute neutralization titers against SARS-CoV-2 by a standardized virus neutralization assay allows for cross-cohort comparisons of COVID-19 sera

, 2020
Kasopefoluwa Y. Oguntuyo, Christian S. Stevens, Chuan-Tien Hung, Satoshi Ikegame, Joshua A. Acklin, Shreyas Kowdle, Jillian C. Carmichael, Hsin-Ping Chiu, Kristopher D. Azarm, Griffin D. Haas, Fatima Amanat, Jéromine Klingler, Ian Baine, Suzanne Arinsburg, Juan C. Bandrés, Mohammed Nure Alam Siddiquey, Robert M. Schilke, Matthew D. Woolard, Hongbo Zhang, J. Andrew Duty, Thomas Kraus, Thomas M. Moran, Domenico Tortorella, Jean K. Lim, Andrea V. Gamarnik, Catarina E. Hioe, Susan Zolla‐Pazner, Stanimir S. Ivanov, Jeremy P. Kamil, Florian Krammer, Benhur Lee   +30 more
openalex   +1 more source

RESP2: An Uncertainty Aware Multi‐Target Multi‐Property Optimization AI Pipeline for Antibody Discovery

Advanced Science, EarlyView.
RESP2, an enhanced antibody discovery pipeline for multi‐target and multi‐property optimization, identifies antibodies with optimized developability and broad affinity to multiple antigen variants. In silico evaluation shows RESP2 outperforms leading AI methods, achieving ≥85% success rates.
Jonathan Parkinson, Ryan Hard, Young Su Ko, Wei Wang   +3 more
wiley   +1 more source

“Recordando la parotiditis en la era del SARS-CoV-2”

, 2000
Anabela Salgueiro Marques, Joana Diogo, Carolina Gomes Coelho   +2 more
openalex   +1 more source

Serological signatures of SARS-CoV-2 infection: Implications for antibody-based diagnostics

, 2020
Jason Rosado, Stéphane Pelleau, Charlotte Cockram, Sarah H. Merkling, Narimane Nekkab, Caroline Demeret, Annalisa Meola, Solen Kernéis, Benjamin Terrier, Samira Fafi‐Kremer, de Sèze, François Déjardin, Stéphane Pêtres, Rhea J. Longley, Marija Backović, Ivo Müeller, Michael White   +16 more
openalex   +1 more source

Engineered Dual‐Function Antibody‐Like Proteins to Combat SARS‐CoV‐2‐Induced Immune Dysregulation and Inflammation

Advanced Science, EarlyView.
Engineered antibody‐like proteins block the SARS‐CoV‐2 spike protein from binding to host receptors and suppress immune overactivation through an MBL‐based scaffold. These dual‐function proteins effectively alleviate inflammation, complement activation, and lung injury, offering a promising therapeutic strategy against severe COVID‐19 and its ...
Yizhuo Wang, Chenwu Bai, Kerui Hou, Zhen Zhang, Ming Guo, Xin Wang, Fan Yang, Xin Liu   +7 more
wiley   +1 more source

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

International Journal of Antimicrobial Agents, 2020
Chih-Cheng Lai, Tzu-Ping Shih, W. Ko, H. Tang, P. Hsueh   +4 more
semanticscholar   +1 more source

Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction

, 2005
T HO, Shikui Wu, Jen‐Ping Chen, Y WEI, S CHENG, Yu-Jen Chang, Hui-Yueh Liu, Chien‐Yun Hsiang   +7 more
openalex   +1 more source

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2

, 2020
Sarah A. Clark, Lars E. Clark, Junhua Pan, Adrian Coscia, Lindsay G. A. McKay, Sundaresh Shankar, Rebecca I. Johnson, Anthony Griffiths, Jonathan Abraham   +8 more
openalex   +1 more source

ADAR1 as a Placental Innate Immune Rheostat Sustaining the Homeostatic Balance of Intrinsic Interferon Response at the Maternal‐Fetal Interface

Advanced Science, EarlyView.
This study reveals that ADAR1, an RNA‐editing enzyme, fine‐tunes immune responses in the placenta by preventing the accumulation of immunogenic double‐stranded RNAs (dsRNAs) from interferon‐stimulated genes. The loss of ADAR1 in the placenta leads to excessive interferon signaling restricted to the junctional zone, disrupting placental development and ...
Xiaogang Chen, Xiangchao Xu, Jiahao Chen, Huiru Zhang, Wanshan Zheng, Wenzhe Yu, Xiaoqian Hu, Bin Cao   +7 more
wiley   +1 more source