Results 181 to 190 of about 1,242,031 (332)

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

, 2020
Susanna K. Elledge, Xin Zhou, James R. Byrnes, Alexander J. Martinko, Irene Lui, Katarina Pance, Shion A. Lim, Jeff E. Glasgow, Anum Glasgow, Keirstinne Turcios, Nikita S. Iyer, Leonel Torres, Michael J. Peluso, Timothy J. Henrich, Taia T. Wang, Cristina M. Tato, Kevin K. Leung, Bryan Greenhouse, James A. Wells   +18 more
openalex   +1 more source

SCORCH2: A Generalized Heterogeneous Consensus Model for High‐Enrichment Interaction‐Based Virtual Screening

Advanced Science, EarlyView.
Researchers developed SCORCH2, an advanced machine‐learning scoring function for virtual screening that combines two complementary XGBoost models to re‐evaluate protein‐ligand binding plausibility. The method demonstrates superior performance on standard benchmarks, shows excellent generalization to previously unseen protein targets, and provides ...
Lin Chen, Vincent Blay, Pedro J. Ballester, Douglas R. Houston   +3 more
wiley   +1 more source

MINERVA: A facile strategy for SARS-CoV-2 whole genome deep sequencing of clinical samples

, 2020
Chen Chen, Jizhou Li, Lin Di, Qiuyu Jing, Pengcheng Du, Chuan Song, Jiarui Li, Qiong Li, Yunlong Cao, Xiaohui Xie, Angela Ruohao Wu, Hui Zeng, Yanyi Huang, Jianbin Wang   +13 more
openalex   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

Advanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil, Josh J. Friesen, Nuthan V. Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y. S. Kong, Andrew J. Varley, Shigeki J. Miyake‐Stoner, Parinaz Aliahmad, Nathaniel S. Wang, Andrew J. Geall, Anna K. Blakney   +12 more
wiley   +1 more source

The influence of pH on SARS-CoV-2 infection and COVID-19 severity

, 2020
Leandro Jimenez, Ana Campos Codo, Vanderson de Souza Sampaio, Antônio Edson Rocha Oliveira, Lucas Kaoru Kobo Ferreira, Gustavo Gastão Davanzo, Lauar de Brito Monteiro, João Victor Virgílio-da-Silva, Mayla Gabriela Silva Borba, Gabriela Fabiano de Souza, Nathália Zini, Flora de Andrade Gandolfi, S. Murano, José Luiz Proença‐Módena, Fernando Val, Gisely Cardoso de Melo, Wuelton Marcelo Monteiro, Maurício Lacerda Nogueira, Marcus Lacerda, Pedro M. Moraes‐Vieira, Helder I. Nakaya   +20 more
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Highly Efficient Air Sterilization via Low‐Temperature Interfacial Evaporation in Inductively Heated Superhydrophilic Ferromagnetic Filters

Advanced Science, EarlyView.
The first low‐temperature interfacial evaporation air sterilization technology is presented. It is based on a superhydrophilic ferromagnetic micro/nano‐structured stainless‐steel filter, showing ultra‐efficient inductive heating. This technology has demonstrated over 99.6% of SARS‐CoV‐2 and RSV elimination at temperatures in the 60–80 °C range.
Arnau Fons, Cristina Vaca, Eloi Franco‐Trepat, Aritz Lafuente, José Luis Tajada, Albert Serrà, Jorge Diaz Pedroza, Sandra Franco, Rytis Boreika, Itziar Erkizia, Nuria Izquierdo‐Useros, Alberto López‐Ortega, Eneko Garaio, Maria Jose Esplandiu, Josep Nogues, Borja Sepúlveda   +15 more
wiley   +1 more source

SARS-CoV-2 receptor ACE2 is expressed in human conjunctival tissue, especially in diseased conjunctival tissue

, 2020
Shengjie Li, Danhui Li, Jianchen Fang, Qiang Liu, Wenjun Cao, Xinghuai Sun, Gezhi Xu   +6 more
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Novel Swelling‐Lytic Cell Death Triggered by Cargo‐Free Ionizable Lipid Nanoparticles

Advanced Science, EarlyView.
A cargo‐free ionizable lipid nanoparticles (ipLNP) is found to induce broad swelling‐lytic cell death across multiple cell types. Cell death may be associated with lysosome membrane destabilization, involving ROS increase, lipid peroxidation, and GSDME cleavage.
Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng, Songying Ouyang   +13 more
wiley   +1 more source

Tracking the introduction and spread of SARS-CoV-2 in coastal Kenya

, 2020
George Githinji, Zaydah R. de Laurent, Khadija Said Mohammed, Donwilliams O. Omuoyo, Peter M. Macharia, John Mwita Morobe, Edward Otieno, Samson Kinyanjui, Ambrose Agweyu, Eric K. Maitha, Ben Kitole, Thani Suleiman, Mohamed S. Mwakinangu, John K. Nyambu, John Ochieng Otieno, Barke Salim, Kadondi Kasera, John Kiiru, Rashid Aman, Edwine Barasa, George M. Warimwe, Philip Bejon, Benjamin Tsofa, Lynette Isabella Ochola‐Oyier, D. James Nokes, Charles N. Agoti   +25 more
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Biomolecular Interaction Prediction: The Era of AI

Advanced Science, EarlyView.
This review offers a thorough examination of recent progress in deep learning for predicting biomolecular interactions, including those involving proteins, nucleic acids, and small molecules. It covers data processing strategies, representative model architectures, and evaluation metrics, while highlighting current methodological limitations.
Haoping Wang, Xiangjie Meng, Yang Zhang
wiley   +1 more source