Results 181 to 190 of about 1,274,904 (321)

Copper(II) Inhibition of the SARS‐CoV‐2 Main Protease

Natural Sciences
In an analysis of the structural stability of the coronavirus main protease (Mpro), we identified regions of the protein that could be disabled by cobalt(III)‐cation binding to histidines and cysteines. Here we have extended our work to include copper(II)
Roberto A. Garza‐López, Liam Kwak, Andrew Chung, Gabriel L. Ancajas, John J. Kozak, Harry B. Gray   +5 more
doaj   +1 more source

The Effect of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Mitigation Strategies on Seasonal Respiratory Viruses: A Tale of 2 Large Metropolitan Centers in the United States [PDF]

, 2020
Amy C Sherman, Ahmed Babiker, Andrew Sieben, Alexander Pyden, James P. Steinberg, Colleen S. Kraft, Katia Koelle, Sanjat Kanjilal   +7 more
openalex   +1 more source

NK cell receptor and ligand composition influences the clearance of SARS-CoV-2 [PDF]

, 2021
Wan-Chen Hsieh, En‐Yu Lai, Yuting Liu, Yi‐Fu Wang, Yi-Shiuan Tzeng, Lu Cui, Yun‐Ju Lai, Hsiang‐Chi Huang, Jia‐Hsin Huang, Hung-Chih Ni, Dong-Yan Tsai, Jian‐Jong Liang, Chun‐Che Liao, Ya-Ting Lu, Laurence Jiang, Ming‐Tsan Liu, Jann‐Tay Wang, Sui‐Yuan Chang, Chung‐Yu Chen, Hsing-Chen Tsai, Yao‐Ming Chang, Gerlinde Wernig, Chia-Wei Li, Kuo‐I Lin, Yi‐Ling Lin, Huai‐Kuang Tsai, Yen‐Tsung Huang, Shih‐Yu Chen   +27 more
openalex   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Nanoparticle Adjuvant Design Enhances Germinal Center Responses Targeting Conserved Subdominant Epitopes for Pan‐Coronavirus Vaccine Development

Advanced Science, EarlyView.
Current SARS‐CoV‐2 vaccines generate short‐lived, strain‐specific immunity. A polymeric TLR7 agonist nanoparticle (TLR7‐NP) adjuvant enhances lymph node targeting and promotes early and sustained germinal center responses toward conserved S2 epitopes of the spike protein.
Sijin Huang, Kanella M. Cohen, Liqiang Chen, Xiaowo Kang, Chang Liu, Megan E. Demouth, Wenxia Jiang, Alexander R. Maldeney, Rong Tong, Zunlong Ke, Kartik Chandran, Wei Luo, Qian Yin   +12 more
wiley   +1 more source

Ebsulfur and Ebselen as highly potent scaffolds for the development of potential SARS-CoV-2 antivirals

, 2021
Le-Yun Sun, Cheng Chen, Jian-Peng Su, Jiaqi Li, Zhihui Jiang, Han Gao, Jia‐Zhu Chigan, Huanhuan Ding, Le Zhai, Ke‐Wu Yang   +9 more
openalex   +2 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

Superspreading potential of SARS-CoV-2 Delta variants under intensive disease control measures in China [PDF]

, 2022
Shi Zhao, Zihao Guo, Ka Chun Chong, Daihai He, Maggie Haitian Wang   +4 more
openalex   +1 more source