Results 11 to 20 of about 1,274,904 (321)

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

New England Journal of Medicine, 2020
Aerosol and Surface Stability of SARS-CoV-2 In this research letter, investigators report on the stability of SARS-CoV-2 and SARS-CoV-1 under experimental conditions.
N. van Doremalen, T. Bushmaker, Dylan H. Morris, M. Holbrook, Amandine Gamble, Brandi N. Williamson, A. Tamin, J. Harcourt, N. Thornburg, S. Gerber, J. Lloyd-Smith, E. de Wit, V. Munster   +12 more
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Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

New England Journal of Medicine, 2020
Background Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid nanoparticle–encapsulated mRNA-based vaccine that encodes the prefusion ...
L. Baden, Hana M. El Sahly, B. Essink, K. Kotloff, S. Frey, R. Novak, D. Diemert, S. Spector, N. Rouphael, C. Creech, J. Mcgettigan, Shishir Kehtan, N. Segall, Joel Solis, A. Brosz, C. Fierro, H. Schwartz, K. Neuzil, L. Corey, P. Gilbert, H. Janes, D. Follmann, M. Marovich, J. Mascola, L. Polakowski, J. Ledgerwood, B. Graham, H. Bennett, R. Pajon, C. Knightly, B. Leav, W. Deng, Honghong Zhou, Shu Han, M. Ivarsson, Jacqueline M. Miller, T. Zaks   +36 more
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Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.

Journal of the American Medical Association (JAMA), 2020
Importance In December 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) emerged in China and has spread globally, creating a pandemic. Information about the clinical characteristics of infected patients who require
G. Grasselli, A. Zangrillo, A. Zanella, M. Antonelli, L. Cabrini, A. Castelli, D. Cereda, A. Coluccello, G. Foti, R. Fumagalli, G. Iotti, N. Latronico, L. Lorini, S. Merler, G. Natalini, A. Piatti, M. Ranieri, A. Scandroglio, E. Storti, M. Cecconi, A. Pesenti   +20 more
semanticscholar   +1 more source

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Science, 2020
How SARS-CoV-2 binds to human cells Scientists are racing to learn the secrets of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), which is the cause of the pandemic disease COVID-19. The first step in viral entry is the binding of the viral
R. Yan, Yuanyuan Zhang, Yaning Li, L. Xia, Yingying Guo, Qiang Zhou   +5 more
semanticscholar   +1 more source

The proximal origin of SARS-CoV-2

Nature Medicine, 2020
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-
Kristian G. Andersen, Kristian G. Andersen, A. Rambaut, W. Lipkin, E. Holmes, R. Garry   +5 more
semanticscholar   +1 more source

Detection of SARS-CoV-2 in Different Types of Clinical Specimens.

Journal of the American Medical Association (JAMA), 2020
This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.
Wenling Wang, Yanli Xu, R. Gao, R. Lu, Kai Han, Guizhen Wu, W. Tan   +6 more
semanticscholar   +1 more source

SARS‐CoV‐2 and hypertension

Physiological Reports, 2021
The objective of this review is to give an overview of the pathophysiological effects of the Coronavirus Disease 2019 (COVID‐19) in relation to hypertension (HT), with a focus on the Renin–Angiotensin–Aldosterone System (RAAS) and the MAS receptor. HT is
Briyanth Ravichandran, Daniela Grimm, Marcus Krüger, Sascha Kopp, Manfred Infanger, Markus Wehland   +5 more
doaj   +1 more source

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

Nature Microbiology, 2020
The present outbreak of a coronavirus-associated acute respiratory disease called coronavirus disease 19 (COVID-19) is the third documented spillover of an animal coronavirus to humans in only two decades that has resulted in a major epidemic.
Alexander E. Susan C. Ralph S. Raoul J. Christian Anastasia Gorbalenya Baker Baric de Groot Drosten Gulyaeva H, A. Gorbalenya, S. Baker, R. Baric, R. D. de Groot, C. Drosten, Anastasia A. Gulyaeva, B. Haagmans, C. Lauber, A. M. Leontovich, B. Neuman, Dmitry Penzar, S. Perlman, L. Poon, Dmitry V. Samborskiy, I. Sidorov, I. Sola, J. Ziebuhr   +17 more
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SARS-CoV-2 variants, spike mutations and immune escape

Nature Reviews Microbiology, 2021
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect functional properties and may alter ...
William T. Harvey, A. Carabelli, B. Jackson, Ravindra K. Gupta, E. Thomson, E. Harrison, C. Ludden, R. Reeve, A. Rambaut, S. Peacock, D. Robertson   +10 more
semanticscholar   +1 more source

2019 Novel Coronavirus (COVID-19) Pandemic: Built Environment Considerations To Reduce Transmission. [PDF]

, 2020
With the rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in coronavirus disease 2019 (COVID-19), corporate entities, federal, state, county, and city governments, universities, school districts, places of worship,
Coil, David A, Dietz, Leslie, Eisen, Jonathan A, Fretz, Mark, Horve, Patrick F, Van Den Wymelenberg, Kevin   +5 more
core   +2 more sources