Results 221 to 230 of about 1,274,904 (321)

Development of SARS-CoV-2 as a viral vector: A novel intranasal bivalent vaccine for SARS-CoV-2 and RSV. [PDF]

Sci Adv
Xu J, Chamblee M, Jiang F, Kc M, Hsu CC, Thongpan I, Chen P, Zhang Y, Chiu CT, Shamseldin MM, Amer HM, Liang X, Amer AO, Boyaka PN, Cormet-Boyaka E, Peeples ME, Li J.   +16 more
europepmc   +1 more source

Medicago Sativa L. Saponin‐Driven Lactobacillus Intestinalis Restores Intestinal Stemness in Naturally Aged Mice via the Bile Acid‐FXR‐Wnt Signaling Axis

Advanced Science, EarlyView.
This study examines the mechanism by which alfalfa saponin (AS) regulates intestinal stemness via modulation of the gut microbiota. The results indicate that AS significantly increases the abundance of Lactobacillus intestinalis, which subsequently activates Wnt signaling via bile acid metabolism and enhances intestinal stemness. These findings provide
Mengqi Liu, Jiamin Sun, Zuyang Jia, Yalei Cui, Xiaoyan Zhu, Zhichang Wang, Hao Sun, Boshuai Liu, Yinghua Shi   +8 more
wiley   +1 more source

Investigating the evolutionary dynamics and mutational pattern of SARS-CoV-2 spike gene on selected SARS-CoV-2 variants. [PDF]

PLoS One
Balech B, Lo Presti A, Telegrafo C, Maisto L, Giombini E, Di Martino A, Ambrosio L, Tullo A, Stefanelli P, Italian Genomic Laboratory Network.   +9 more
europepmc   +1 more source

Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response

, 2022
Gustavo Garcia, Arjit Vijey Jeyachandran, Yijie Wang, Joseph Ignatius Irudayam, Sebastian Castillo Cario, Chandani Sen, Li Shen, Yunfeng Li, Ashok Kumar, Karin Nielsen‐Saines, Samuel W. French, Priya S. Shah, Kouki Morizono, Brigitte N. Gomperts, Arjun Deb, Arunachalam Ramaiah, Vaithilingaraja Arumugaswami   +16 more
openalex   +2 more sources

Investigation into the Pancreatic Pathogenesis of SFTSV across Multiple Levels

Advanced Science, EarlyView.
A retrospective analysis revealed that 17.6% of severe fever with thrombocytopenia syndrome (SFTS) patients met the diagnostic criteria for clinically confirmed pancreatitis. Using human pancreatic organoids and murine models demonstrated that SFTSV exhibits a specific pancreatic tropism, leading to cell death and initiating a strong inflammatory ...
Xiaohan Liu, Zhihao Xu, Yilun Tong, Changtai Wang, Yueqi Yao, Yujie Diao, Jingyuan Ma, Shijun Zhou, Yinan Du, Zhenhua Zhang, Gang Xu   +10 more
wiley   +1 more source

Lung infection in orally inoculated SARS-CoV-2 hamsters. [PDF]

PLoS One
Picard-Meyer E, Wasniewski M, Boué F, Torres-Maravilla E, Saint-Criq V, Larcher T, Beissat K, Jacouton E, Holowacz S, Waligora-Dupriet AJ, Langella P, Servat A, Monchatre-Leroy E.   +12 more
europepmc   +1 more source

Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection

, 2020
Kun Han, Robert V. Blair, Naoki Iwanaga, Fengming Liu, Kasi Russell‐Lodrigue, Zhongnan Qin, Cecily C. Midkiff, Nadia Golden, Lara Doyle‐Meyers, Mohammad E. Kabir, Kristin Chandler, Kellie L. Cutrera, Mi Ren, Christopher Monjure, Gabrielle Lehmicke, Tracy Fischer, Brandon J. Beddingfield, Alanna Wanek, Angela K. Birnbaum, Nicholas J. Maness, Chad J. Roy, Prasun K. Datta, Jay Rappaport, Jay K. Kolls, Xuebin Qin   +24 more
openalex   +2 more sources

Allosteric Cross-Talk among Spike’s Receptor-Binding Domain Mutations of the SARS-CoV-2 South African Variant Triggers an Effective Hijacking of Human Cell Receptor

, 2021
Angelo Spinello, Andrea Saltalamacchia, Jure Borišek, Alessandra Magistrato   +3 more
openalex   +2 more sources

Mucin‐Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity

Advanced Science, EarlyView.
Virucidal polymers serve as effective antivirals by not only inhibiting viruses but also destroying them. Inspired by the chemical properties of mucin‐mimetics, dendronized polyglycerol‐sulfated, mucin‐inspired amphiphilic copolymers (MIACPs) have been developed.
Raju Bej, Enyu Xie, Kai Ludwig, Robert F. Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben, Rainer Haag   +10 more
wiley   +1 more source

SARS-CoV-2 Detection and Persistence in a Remote Amazonian Settlement. [PDF]

J Trop Med
Silva GM, Ilacqua RC, Gonçalves FG, Santana CM, Jordão FT, Prist PR, Nolan MS, Brilhante AF, Sperança MA, Laporta GZ.   +9 more
europepmc   +1 more source