Results 221 to 230 of about 24,947,200 (233)

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants. [PDF]

PLoS Pathog
Acuña JA, Gabriel B, Ayyanathan K, Miller J, Li Y, Whig K, Zhu Y, McGrath M, Hewins P, Jurado KA, Frieman MB, Schultz DC, Cherry S.   +12 more
europepmc   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Editorial: SARS-CoV-2 vaccines beyond the pandemic era, volume II. [PDF]

Front Med (Lausanne)
Bao S, Rahimi F, Yorsaeng R.
europepmc   +1 more source

Hyperglycemia in Cats Infected by SARS-CoV-2: Pancreatic Alterations and Potential Antiviral Therapeutics. [PDF]

Microorganisms
Onodera T, Seo S, Sakudo A, Toniolo A.
europepmc   +1 more source

Low‐Concentration Enhancement Effect: Enabling Sensitive Detection of EML4‐ALK Variants via Multiplex RT‐MIRA

Journal of Clinical Laboratory Analysis, EarlyView.
This study developed an optimized multiplex RT‐MIRA assay for the simultaneous detection of EML4‐ALK variants, achieving single‐copy sensitivity. Unexpectedly, during the development of the reaction system, we discovered a “low‐concentration enhancement effect,” where reducing primer or probe concentrations within a specific range markedly improved ...
Xiao‐Dong Ren, Xi‐Yao Luo, Jin‐Mi Li, Xian‐Ge Sun, Jing Lv, Hua‐Liang Xiao, Qiu‐Shi Wang, Hong Wang, Chun‐Yan Wang, Hao‐Zheng Li, Qing Huang   +10 more
wiley   +1 more source

SARS-CoV-2 and reproductive system: a scientometric study. [PDF]

Front Reprod Health
Zhang L, Wang M, Zhang H, Mao G.
europepmc   +1 more source

Association of IFN‐γ +874 T/A Polymorphism With COVID‐19 Susceptibility, Severity, and Inflammatory Response: A Case–Control Study From Southern Iran

Journal of Clinical Laboratory Analysis, EarlyView.
Graphical abstract illustrating the association between IFN‐γ +874 T/A polymorphism and COVID‐19 outcomes. TA and AA genotypes are linked to increased susceptibility, higher inflammatory markers (notably IL‐6), greater disease severity, and longer hospitalization.
Nasir Arefinia, Bahman Aghcheli, Seyed Mohammad Ali Hashemi, Zohreh‐al‐sadat Ghoreshi, Emad Behboudi   +4 more
wiley   +1 more source

Heritable transgenic schistosomes as a living platform for SARS-CoV-2 neutralizing antibody secretion. [PDF]

Nat Commun
Ittiprasert W, Smout MJ, Mann VH, Moyle M, Kinahan SM, Ackerman DN, Rivera DN, Santarpia JL, Carnes EC, Mentink-Kane MM, Costa MR, Hokke CH, Roestenberg M, Bottazzi ME, Bracken BK, Rosa BA, Djuranovic S, Pickering DA, Giacomin PR, Watterson D, Modhiran N, Moescheid MF, Grevelding CG, Mitreva M, Loukas A, Brindley PJ.   +25 more
europepmc   +1 more source