Results 261 to 270 of about 1,274,904 (321)

The Effect of SARS-CoV-2 Reinfection on Long-Term Symptoms in the Innovative Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE). [PDF]

Clin Infect Dis
Openshaw JJ, Chen J, Rodriguez R, Gottlieb M, McCullough K, Santangelo M, Hill MJ, Gatling K, Idris AH, Idris AH, McDonald S, Wisk LE, Dyal J, Wang RC, Rising KL, Kean E, O'Laughlin KN, Stephens KA, Malicki C, Lin Z, Spatz ES, Yu H, Weinstein RA, Elmore J.   +23 more
europepmc   +1 more source

Genomic diversity and surveillance of SARS-CoV-2 in Nigeria. [PDF]

BMC Genomics
Kono TJY, Onyemata EJ, Blanco N, Onwuamah CK, Ndodo N, Oluniyi P, Lawal O, Riley C, Osawe S, Baxter C, Winters A, Xiong C, Happi CT, Salako BL, Adetifa I, Abimiku A, Charurat M, Stafford KA, INFORM Africa Research Study Group.   +18 more
europepmc   +1 more source

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane

Angewandte Chemie, EarlyView.
The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi, Ayumi Kikkawa, Seigo Kimura, Hiroshi Abe, Shiroh Futaki   +4 more
wiley   +2 more sources

The Effect of SARS-COV-2 Protein Fragments on the Dimerization of α-Synuclein. [PDF]

ACS Chem Neurosci
Coleman LM, Hansmann UHE.
europepmc   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR‐Spectroscopy

Angewandte Chemie, EarlyView.
Diazirines are three‐membered, nitrogen‐containing heterocycles that decompose under light or heat to generate carbenes. For the past two decades, they have served mainly as minimally invasive tags in photoaffinity labeling (PAL). More recently, their value as versatile carbene precursors has been recognized.
Dominik Schnalzer, Viktor Savic, Clemens Cziegler, Michael Schnürch, Marko D. Mihovilovic   +4 more
wiley   +2 more sources

Pathways in the brain, heart and lung influenced by SARS-CoV-2 NSP6 and SARS-CoV-2 regulated miRNAs: an in silico study hinting cancer incidence. [PDF]

Cardiooncology
Chatterjee S, Mahata J, Kateriya S, Anirudhan G.   +3 more
europepmc   +1 more source

Multimorbidity and animal models

Animal Models and Experimental Medicine, EarlyView.
Multimorbidity, defined as the coexistence of ≥2 chronic conditions, is associated with aging, genetics, and environmental factors. Animal models in multimorbidity research span three tiers: simple organisms for initial screening → rodents for mechanistic analysis → large mammals for clinical prediction.
Xinpei Wang, Yakun Ren, Xingjiu Yang, Mengyuan Li, Junxiu Liu, Xiaoyan Du, Wen Wang, Ran Gao   +7 more
wiley   +1 more source

Co-Infection With Hepatitis E Virus and SARS-CoV-2 in a Lymphoma Patient. [PDF]

J Med Virol
Boucetta Y, Boschi C, Peroni E, Jean R, Bories E, Borentain P, Andreani J, Colson P.   +7 more
europepmc   +1 more source