Results 31 to 40 of about 1,242,031 (332)

SARS-CoV-2 variants, spike mutations and immune escape

Nature Reviews Microbiology, 2021
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome are expected to be either deleterious and swiftly purged or relatively neutral, a small proportion will affect functional properties and may alter ...
William T. Harvey, A. Carabelli, B. Jackson, Ravindra K. Gupta, E. Thomson, E. Harrison, C. Ludden, R. Reeve, A. Rambaut, S. Peacock, D. Robertson   +10 more
semanticscholar   +1 more source

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

Nature, 2020
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, K. Obernier, K. White, Matthew J. O’Meara, V. Rezelj, Jeffrey Z. Guo, D. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia L. Richards, B. Tutuncuoglu, Helene Foussard, J. Batra, Kelsey M. Haas, Mayank Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, M. J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, F. Roesch, T. Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, S. Peng, Ying Shi, Ziyang Zhang, W. Shen, I. T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, D. Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J. P. Mathy, Tina Perica, K. B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, R. Rakesh, Xi Liu, S. Rosenthal, Lorenzo Calviello, S. Venkataramanan, José M Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, Yongfeng Liu, S. Wankowicz, M. Bohn, M. Safari, Fatima S. Ugur, C. Koh, Nastaran Sadat Savar, Q. D. Tran, Djoshkun Shengjuler, S. Fletcher, M. C. O’Neal, Yiming Cai, Jason C. J. Chang, D. Broadhurst, Saker Klippsten, P. P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, R. Trenker, Janet M. Young, D. A. Cavero, J. Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, R. Stroud, A. Frankel, O. Rosenberg, K. Verba, D. Agard, M. Ott, M. Emerman, N. Jura, M. von Zastrow, E. Verdin, A. Ashworth, O. Schwartz, C. d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, D. Fujimori, T. Ideker, C. Craik, S. Floor, J. Fraser, J. Gross, A. Sali, B. Roth, D. Ruggero, J. Taunton, T. Kortemme, P. Beltrão, M. Vignuzzi, A. García-Sastre, K. Shokat, B. Shoichet, N. Krogan   +124 more
semanticscholar   +1 more source

Portable real-time colorimetric LAMP-device for rapid quantitative detection of nucleic acids in crude samples

Scientific Reports, 2022
Loop-mediated isothermal amplification is known for its high sensitivity, specificity and tolerance to inhibiting-substances. In this work, we developed a device for performing real-time colorimetric LAMP combining the accuracy of lab-based quantitative ...
G. Papadakis, A. K. Pantazis, N. Fikas, S. Chatziioannidou, V. Tsiakalou, K. Michaelidou, V. Pogka, M. Megariti, M. Vardaki, K. Giarentis, J. Heaney, E. Nastouli, T. Karamitros, A. Mentis, A. Zafiropoulos, G. Sourvinos, S. Agelaki, E. Gizeli   +17 more
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Acute parkinsonism secondary to SARS Cov 2 infection. [PDF]

Batna Journal of Medical Sciences, 2023
SARS Cov 2 or Corona virus is a respiratory virus, responsible for a new pandemic since 2019. Main symptoms revolve around respiratory manifestations. Nevertheless, many extra-respiratory attacks are attributed to it.
Mohamed Islam Kediha, Dalila Moualek, Mahdia Hamalit, Lamia Ali Pacha   +3 more
doaj   +1 more source

Mechanisms of SARS-CoV-2 entry into cells

Nature reviews. Molecular cell biology, 2021
The unprecedented public health and economic impact of the COVID-19 pandemic caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been met with an equally unprecedented scientific response.
C. B. Jackson, M. Farzan, Bing Chen, H. Choe   +3 more
semanticscholar   +1 more source

Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 [PDF]

, 2020
Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported.
Boon, Paul, De Herdt, Veerle, Garrez, Ieme, Hemelsoet, Dimitri, Laureys, Guy, Raedt, Robrecht, Vonck, Kristl   +6 more
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Cardiovascular disease in SARS‐CoV‐2 infection

Clinical & Translational Immunology, 2021
Pre‐existing cardiovascular disease (CVD) increases the morbidity and mortality of COVID‐19 and is strongly associated with poor disease outcomes. However, SARS‐CoV‐2 infection can also trigger de novo acute and chronic cardiovascular disease.
Kei Sato, Jane E Sinclair, Habib Sadeghirad, John F Fraser, Kirsty R Short, Arutha Kulasinghe   +5 more
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Evolutionary Dynamics and Dissemination Pattern of the SARS-CoV-2 Lineage B.1.1.33 During the Early Pandemic Phase in Brazil

Frontiers in Microbiology, 2021
A previous study demonstrates that most of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Brazilian strains fell in three local clades that were introduced from Europe around late February 2020.
Paola Cristina Resende, Edson Delatorre, Tiago Gräf, Daiana Mir, Fernando Couto Motta, Luciana Reis Appolinario, Anna Carolina Dias da Paixão, Ana Carolina da Fonseca Mendonça, Maria Ogrzewalska, Braulia Caetano, Gabriel Luz Wallau, Cássia Docena, Mirleide Cordeiro dos Santos, Jessylene de Almeida Ferreira, Edivaldo Costa Sousa Junior, Sandro Patroca da Silva, Sandra Bianchini Fernandes, Lucas Alves Vianna, Larissa da Costa Souza, Jean F. G. Ferro, Vanessa B. Nardy, Cliomar A. Santos, Irina Riediger, Maria do Carmo Debur, Júlio Croda, Júlio Croda, Wanderson K. Oliveira, André Abreu, Gonzalo Bello, Marilda M. Siqueira   +29 more
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Coronavirus in Continuous Flux: From SARS‐CoV to SARS‐CoV‐2

Advanced Science, 2020
The world is currently experiencing a global pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), which causes severe respiratory disease similar to SARS.
Yetian Dong, Tong Dai, Jun Liu, Long Zhang, Fangfang Zhou   +4 more
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Racing for a SARS‐CoV‐2 vaccine

EMBO Molecular Medicine, 2021
Graphical Abstract Interview with EMBO Members Özlem Türeci and Uğur Şahin, BioNTech, conducted by science journalist Kai Kupferschmidt.
Özlem Türeci, Uğur Şahin
doaj   +1 more source