Results 61 to 70 of about 24,947,200 (233)

Susceptibility of lung cancer patients to COVID‐19: A review of the pandemic data from multiple nationalities

Thoracic Cancer, 2021
Several studies have highlighted that cancer patients tend to be more susceptible to develop severe infection and to die from COVID‐19. Certain medical conditions such as immunosuppression, presence of comorbidities, and underlying pulmonary damage are ...
Ana Emília Goulart Lemos, Gabriela Ribeiro Silva, Etel Rodrigues Pereira Gimba, Aline da Rocha Matos   +3 more
doaj   +1 more source

Prevalence of Anti-SARS-CoV-2 Antibodies and Potential Determinants among the Belgian Adult Population: Baseline Results of a Prospective Cohort Study

, 2022
The prevalence of anti-SARS-CoV-2 antibodies and potential determinants were assessed in a random sample representative of the Belgian adult population.
Cyril Barbezange, L. Gisle, Leclercq, Victoria, Desombere, Isabelle, Victoria Leclercq, Isabelle Desombere, N. Van den Houte, J. Van der Heyden, Gisle, Lydia, Inge Roukaerts, I. Roukaerts, Roukaerts, Inge, Els Duysburgh, Barbezange, Cyril, V. Leclercq, E. Duysburgh, C. Barbezange, Van der Heyden, Johan, Johan Van der Heyden, Van den Houte, Nayema, Nayema Van den Houte, Lydia Gisle, I. Desombere, Duysburgh, Els   +23 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza vaccine and a naturally occurring cowpox virus

Frontiers in Immunology
Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as recombinant vector vaccine against infectious diseases and cancers in humans and animals.
Diana Diaz-Cánova, Ugo Moens, Annika Brinkmann, Andreas Nitsche, Malachy Ifeanyi Okeke   +4 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV

, 2020
After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections.
Yunlong Wang, Guo, Xiangqian, Xu, Jiabao, Wan Zhu, Jiabao Xu, Shizhe Zhao, Xiangqian Guo, Wang, Yunlong, Zhao, Shizhe, Abdalla, E. Abualgasim, Abualgasim Elgaili Abdalla, Xie, Longxiang, Longxiang Xie, Zhu, Wan, Tieshan Teng, Teng, Tieshan   +15 more
core   +1 more source

Immunosuppression as a Hub for SARS-CoV-2 Mutational Drift

, 2023
The clinical course of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is largely determined by host factors, with a wide range of outcomes.
Tal Patalon, Noam Shomron, Sivan Gazit, Guy Shapira   +3 more
core   +1 more source

Mutations and Evolution of the SARS-CoV-2 Spike Protein [PDF]

, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Michael C. McGee, Zhang, Tianyi, Tianyi Zhang, Yingying Wu, Magazine, Nicholas, Wu, Yingying, Weishan Huang, Gianluca Veggiani, Veggiani, Gianluca, Nicholas Magazine, Huang, Weishan, McGee, Michael C.   +11 more
core   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Follow-up SARS-CoV-2 serological study of a health care worker cohort following COVID-19 booster vaccination

BMC Infectious Diseases
Background Studies have shown that Omicron breakthrough infections can occur at higher SARS-CoV-2 antibody levels compared to previous variants. Estimating the magnitude of immunological protection induced from COVID-19 vaccination and previous infection
Alexander Hönning, Sara Tomczyk, Julia Hermes, Marica Grossegesse, Natalie Hofmann, Janine Michel, Markus Neumann, Andreas Nitsche, Berthold Hoppe, Tim Eckmanns, Hajo Schmidt-Traub, Kristina Zappel   +11 more
doaj   +1 more source