Results 171 to 180 of about 1,228,387 (374)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

open access: yesAdvanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac   +7 more
wiley   +1 more source

Surveillance of seasonal respiratory viruses among Chilean patients during the COVID‐19 pandemic

open access: yesHealth Science Reports, 2021
Luis A. Alonso‐Palomares   +8 more
doaj   +1 more source

Functionalized Antifouling Polymer Brushes for Biospecific Surfaces

open access: yesAdvanced Materials Interfaces, EarlyView.
Modern biosensors offer high sensitivity but often struggle with long‐term stability and selectivity for specific targets. Antifouling polymer brushes help enhance both stability and selectivity. In this review, we compare recent antifouling coatings, their design parameters, and how they are integrated with biorecognition elements for improved ...
Erik J. Postma   +4 more
wiley   +1 more source

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

open access: yesNature, 2020
J. Lan   +10 more
semanticscholar   +1 more source

Leveraging Design of Experiments to Unravel the Amplification Mechanism of Single‐Molecule Wide‐Field Biosensors

open access: yesAdvanced Materials Interfaces, EarlyView.
Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio   +9 more
wiley   +1 more source

Advancing COVID-19 diagnostics:rapid detection of intact SARS-CoV-2 using viability RT-PCR assay [PDF]

open access: yes
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Commonly used methods for both clinical diagnosis of SARS-CoV-2 infection and management of infected patients involve the detection of viral RNA, but
Dickman, Mor M.   +12 more
core   +1 more source

Fetal Surgery in the Era of SARS-CoV-2 Pandemic: A Single-Institution Review [PDF]

open access: gold, 2020
Kavita Narang   +10 more
openalex   +1 more source

Well‐Defined Poly(HPMAm) Brushes via Surface‐Initiated RAFT Polymerization; A Mixed‐Chain Transfer Agent (CTA) Approach

open access: yesAdvanced Materials Interfaces, EarlyView.
A simple method relying on surface‐initiated RAFT polymerization is presented using a mixed‐chain transfer agent (mixed‐CTA) approach to grow well‐defined poly(HPMAm) brushes with precise control, achieving >70 nm thickness in 4 h at moderate temperature, 50 °C. Abstract Over three decades, efforts to prevent non‐specific protein adsorption on surfaces
Manisha Singh   +4 more
wiley   +1 more source

Photonic Crystal Enhanced Microscopy on a 2D Photonic Crystal Surface

open access: yesAdvanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This work demonstrates the design, fabrication, and the first‐time test of a 2D photonic crystal surface for photonic resonator absorption microscopy. The designed surface uniformly enhances electromagnetic near fields, achieving > 100% improved detecting uniformity for surface‐captured AuNPs from a blocking biosensor assay aimed for detecting SARS‐CoV‐
Weinan Liu   +5 more
wiley   +1 more source

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

open access: yesNature Network Boston, 2021
D. Khoury   +9 more
semanticscholar   +1 more source

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